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Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance.

International journal of cancer, April 1, 2016, Vol.138(7), pp.1645-1656 [Peer Reviewed Journal]

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Effect of noncompetitive proteasome inhibition on bortezomib resistance.

Journal of the National Cancer Institute, July 21, 2010, Vol.102(14), pp.1069-1082 [Peer Reviewed Journal]

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Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance.

Clinical cancer research : an official journal of the American Association for Cancer Research, December 1, 2011, Vol.17(23), pp.7337-7346 [Peer Reviewed Journal]

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Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines.

The Journal of antimicrobial chemotherapy, August 2010, Vol.65(8), pp.1672-1680 [Peer Reviewed Journal]

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Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia.

Journal of hematology & oncology, May 29, 2015, Vol.8, p.61 [Peer Reviewed Journal]

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Bortezomib resistance in multiple myeloma is associated with increased serine synthesis

Cancer & Metabolism, 2017 [Peer Reviewed Journal]

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Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines

The Biochemical journal, 01 November 2002, Vol.367(Pt 3), pp.741-50 [Peer Reviewed Journal]

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(Immuno)proteasomes as therapeutic target in acute leukemia

Cancer and Metastasis Reviews, 2017, Vol.36(4), pp.599-615 [Peer Reviewed Journal]

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Positioning of proteasome inhibitors in therapy of solid malignancies

Cancer Chemotherapy and Pharmacology, 2018, Vol.81(2), pp.227-243 [Peer Reviewed Journal]

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Loss of folylpoly-γ-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines

International Journal of Cancer, 20 February 2003, Vol.103(5), pp.587-599 [Peer Reviewed Journal]

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by this Author/Contributor:

  1. Jansen, Gerrit
  2. Jansen, G
  3. Rheumatology
  4. Assaraf, Yehuda G.
  5. Assaraf, Y.G.

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