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INTERLEUKIN-6 STIMULATES GENE-EXPRESSION OF EXTRACELLULAR-MATRIX COMPONENTS IN BOVINE MESANGIAL CELLS IN CULTURE

Mediators Of Inflammation, 1993 Dec, Vol.2(6), pp.429-433 [Peer Reviewed Journal]

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  • Title:
    INTERLEUKIN-6 STIMULATES GENE-EXPRESSION OF EXTRACELLULAR-MATRIX COMPONENTS IN BOVINE MESANGIAL CELLS IN CULTURE
  • Author: Zoja, C ; Benigni, A ; Piccinini, G ; Figliuzzi, M ; Longaretti, L ; Remuzzi, G
  • Found In: Mediators Of Inflammation, 1993 Dec, Vol.2(6), pp.429-433 [Peer Reviewed Journal]
  • Subjects: Medicine
  • Language: English
  • Description: The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for alpha1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis.
  • Identifier: ISSN: 0962-9351

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