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Clinical Trials Involving Hypertension

New England Journal Of Medicine, 2017 Jan 19, Vol.376(3), pp.289-290 [Peer Reviewed Journal]

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  • Title:
    Clinical Trials Involving Hypertension
  • Author: Shamy, M ; Fedyk, M
  • Found In: New England Journal Of Medicine, 2017 Jan 19, Vol.376(3), pp.289-290 [Peer Reviewed Journal]
  • Language: English
  • Description: To the Editor: In their comprehensive review of trials examining the efficacy of antihypertensive medications since 1966, Pfeffer and McMurray (Nov. 3 issue) 1 state, “Since the risks and the potential benefits of using pharmacologic agents to reduce blood pressure were unknown, placebo was unquestionably the correct comparator.” This statement is incorrect. In 1967, the Veterans Administration Cooperative Study Group on Antihypertensive Agents 2 commented, “the value of antihypertensive drug treatment in malignant hypertension has been amply demonstrated. . . . [I]ts effectiveness in preventing morbidity and mortality in less severe forms of hypertension has been disputed.” To the Editor: Pfeffer and . . .
  • Identifier: ISSN: 0028-4793

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