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Reaction-Diffusion Systems in Intracellular Molecular Transport and Control

Angewandte Chemie-International Edition, 2010, Vol.49(25), pp.4170-4198 [Peer Reviewed Journal]

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  • Title:
    Reaction-Diffusion Systems in Intracellular Molecular Transport and Control
  • Author: Soh, S ; Byrska, M ; Kandere-Grzybowska, K ; Grzybowski, BA
  • Found In: Angewandte Chemie-International Edition, 2010, Vol.49(25), pp.4170-4198 [Peer Reviewed Journal]
  • Subjects: Bioenergetics ; Eukaryotes ; Intracellular Transport ; Prokaryotes ; Systems Chemistry
  • Language: English
  • Description: Chemical reactions make cells work only if the participating chemicals are delivered to desired locations in a timely and precise fashion. Most research to date has focused on active‐transport mechanisms, although passive diffusion is often equally rapid and energetically less costly. Capitalizing on these advantages, cells have developed sophisticated reaction‐diffusion (RD) systems that control a wide range of cellular functions—from chemotaxis and cell division, through signaling cascades and oscillations, to cell motility. These apparently diverse systems share many common features and are “wired” according to “generic” motifs such as nonlinear kinetics, autocatalysis, and feedback loops. Understanding the operation of these complex (bio)chemical systems requires the analysis of pertinent transport‐kinetic equations or, at least on a qualitative level, of the characteristic times of the constituent subprocesses. Therefore, in reviewing the manifestations of cellular RD, we also describe basic theory of reaction‐diffusion phenomena. couple chemical reactions with diffusion (in reaction‐diffusion or RD systems) to achieve spatially and temporally coordinated delivery of the molecules to intracellular reaction sites. These cellular RD systems are based on several common architectures and motifs that enable cells to build, operate, and position structures for cell division, gradient sensing, signal transduction and amplification, and cell motility.
  • Identifier: ISSN: 1433-7851 ; DOI: 10.1002/anie.200905513

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