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Electrical signals triggered controllable formation of calcium-alginate film for wound treatment

Journal of Materials Science: Materials in Medicine, 2017, Vol.28(10), pp.1-10 [Peer Reviewed Journal]

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  • Title:
    Electrical signals triggered controllable formation of calcium-alginate film for wound treatment
  • Author: Liu, Xiaoli ; Liu, Huan ; Qu, Xue ; Lei, Miao ; Zhang, Chuchu ; Hong, Hua ; Payne, Gregory ; Liu, Changsheng
  • Found In: Journal of Materials Science: Materials in Medicine, 2017, Vol.28(10), pp.1-10 [Peer Reviewed Journal]
  • Subjects: Collagen ; Wound Care ; Electrochemistry ; Electrochemical Reactions
  • Language: English
  • Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s10856-017-5956-x Byline: Xiaoli Liu (1), Huan Liu (1), Xue Qu (1), Miao Lei (1), Chuchu Zhang (1), Hua Hong (1), Gregory F. Payne (2), Changsheng Liu (1) Abstract: Abstract Wound dressings play important roles in the management of wounds, and calcium cross-linked alginate (Ca.sup.2+-Alg) is a commonly used hydrogel that is adapted for wound treatment. However, conventional methods for fabricating Ca.sup.2+-Alg hydrogels can be tedious and difficult to control because of the rapid Ca.sup.2+-induced gelation of alginate. In this study, An electrodeposition method was used to rapidly and controllably fabricate Ca.sup.2+-Alg films for wound treatment. Several measures of film growth (e.g., thickness and mass) are shown to linearly correlate to the imposed charge transfer at the electrode. Similarly, this charge transfer was also observed to control important physicochemical wound healing properties such as water uptake and retention capacity. Furthermore, a wound healing animal test was performed to evaluate the performance of this electro-fabricated calcium alginate film for wound treatment. This in vivo study demonstrated that wounds dressed with an electro-fabricated Ca.sup.2+-Alg film closed faster than that of untreated wounds. Further, the new dermis tissue that formed was composed of reorganized and stratified epithelial layer, with fully developed connective tissue, hair follicle, sebaceous glands as well as aligned collagen. Therefore, our study indicates that this electrofabrication method for the rapid and controlled preparation of alginate film could provide exciting opportunities for wound treatment. More broadly, this study demonstrates the potential of electrochemistry for the fabrication of high performance polymeric materials. Graphical Abstract Here we report a rapid and controllable fabrication of free-standing alginate films by coupling anodic electrodeposition with subsequent peeling of deposited materials for wound dressing. Author Affiliation: (1) Key Laboratory for Ultrafine Materials of Ministry of Education, The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China (2) Institute for Biosystems and Biotechnology Research and Fischell Department of Bioengineering, 5115 Plant Sciences Building, College Park, MD, 20742, USA Article History: Registration Date: 01/08/2017 Received Date: 22/06/2017 Accepted Date: 01/08/2017 Online Date: 19/08/2017
  • Identifier: ISSN: 0957-4530 ; E-ISSN: 1573-4838 ; DOI: 10.1007/s10856-017-5956-x

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