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Novel application of chemical shift gradient echo in- and opposed-phase sequences in 3 T MRI for the detection of H-MRS visible lipids and grading of glioma

European Radiology, 2016, Vol.26(7), pp.2019-2029 [Peer Reviewed Journal]

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  • Title:
    Novel application of chemical shift gradient echo in- and opposed-phase sequences in 3 T MRI for the detection of H-MRS visible lipids and grading of glioma
  • Author: Ramli, Norlisah ; Khairy, Azua ; Seow, Pohchoo ; Tan, Li ; Wong, Jeannie ; Ganesan, Dharmendra ; Rahmat, Kartini
  • Found In: European Radiology, 2016, Vol.26(7), pp.2019-2029 [Peer Reviewed Journal]
  • Subjects: Lipid phantom ; Magnetic resonance spectroscopy ; Volume under the receiver operating curve surface ; Glioma classification ; In- and opposed-phase imaging
  • Language: English
  • Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00330-015-4045-0 Byline: Norlisah Ramli (1), Azua Mohd Khairy (2), Pohchoo Seow (1), Li Kuo Tan (1), Jeannie Hsiu Ding Wong (1), Dharmendra Ganesan (3), Kartini Rahmat (1) Keywords: Lipid phantom; Magnetic resonance spectroscopy; Volume under the receiver operating curve surface; Glioma classification; In- and opposed-phase imaging Abstract: Objectives We evaluated the feasibility of using chemical shift gradient-echo (GE) in- and opposed-phase (IOP) imaging to grade glioma. Methods A phantom study was performed to investigate the correlation of 1.sup.H MRS-visible lipids with the signal loss ratio (SLR) obtained using IOP imaging. A cross-sectional study approved by the institutional review board was carried out in 22 patients with different glioma grades. The patients underwent scanning using IOP imaging and single-voxel spectroscopy (SVS) using 3T MRI. The brain spectra acquisitions from solid and cystic components were obtained and correlated with the SLR for different grades. Results The phantom study showed a positive linear correlation between lipid quantification at 0.9 parts per million (ppm) and 1.3 ppm with SLR (r=0.79--0.99, p<0.05). In the clinical study, we found that SLR at the solid portions was the best measure for differentiating glioma grades using optimal cut-points of 0.064 and 0.086 with classification probabilities for grade II (S.sub.II=1), grade III (S.sub.III=0.50) and grade IV (S.sub.IV=0.89). Conclusions The results underscore the lipid quantification differences in grades of glioma and provide a more comprehensive characterization by using SLR in chemical shift GE IOP imaging. SLR in IOP sequence demonstrates good performance in glioma grading. Key Points acents Strong correlation was seen between lipid concentration and SLR obtained using IOP acents IOP sequence demonstrates significant differences in signal loss within the glioma grades acents SLR at solid tumour portions was the best measure for differentiation acents This sequence is applicable in a research capacity for glioma staging armamentarium Author Affiliation: (1) Department of Biomedical Imaging, University Malaya Research Imaging Centre, University of Malaya, 59100, Kuala Lumpur, Malaysia (2) Department of Radiology, Sultan Ismail Hospital, Jalan Persiaran Mutiara Emas Utama, Taman Mount Austin, 81100, Johor Bahru, Malaysia (3) Division of Neurosurgery, Department of Surgery, University of Malaya, 59100, Kuala Lumpur, Malaysia Article History: Registration Date: 23/09/2015 Received Date: 03/07/2015 Accepted Date: 23/09/2015 Online Date: 11/11/2015
  • Identifier: ISSN: 0938-7994 ; E-ISSN: 1432-1084 ; DOI: 10.1007/s00330-015-4045-0

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