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Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction

Chemical Communications, 25 May 2015, Vol.51(42), pp.8845-8848 [Peer Reviewed Journal]

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  • Title:
    Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction
  • Author: Wang, B. ; Ren, J. ; Li, L. ; Guo, F. ; Pan, G. ; Ai, G. ; Aigle, B. ; Fan, K. ; Yang, K.
  • Found In: Chemical Communications, 25 May 2015, Vol.51(42), pp.8845-8848 [Peer Reviewed Journal]
  • Subjects: Oxidoreductases -- Metabolism
  • Rights: Copyright 2015 Elsevier B.V., All rights reserved.
  • Description: The biosynthesis of diazobenzofluorene kinamycins requires a hitherto uncharacterized B-ring contraction. Via detailed genetic and enzymatic analyses we unambiguously characterized the conserved pairs of oxidases, AlpJ and AlpK homologs, as nature's machinery for benzofluorenone formation, which paves the way for the investigation of the following diazo assembly.
  • Identifier: ISSN: 13597345 ; E-ISSN: 1364548X ; DOI: 10.1039/c5cc01986a

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