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Checkpoint for gut microbes after birth.

Nature, August 2018, Vol.560(7719), pp.436-438 [Peer Reviewed Journal]

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  • Title:
    Checkpoint for gut microbes after birth.
  • Author: Macpherson, Andrew J ; Ganal-Vonarburg, Stephanie C
  • Contributor: Macpherson, Andrew J (correspondence author) ; Macpherson, Andrew J (record owner)
  • Found In: Nature, August 2018, Vol.560(7719), pp.436-438 [Peer Reviewed Journal]
  • Subjects: Gastrointestinal Microbiome ; Selection, Genetic ; Toll-Like Receptor 5 ; Toll-Like Receptor 5 ; Microbiology ; Microbiome
  • Language: English
  • Description: [...]both beneficial and pathogenic microorganisms will be encountered, and will compete to colonize the baby's body. The immature, vulnerable immune system of a newborn can to some extent be shielded from pathogenic attack by the presence of antibodies from the infant's mother, transferred across the placenta or in breast milk - a particularly effective health-boosting measure. To investigate how postnatal development affects the establishment of the gut microbial community, Fulde and co-workers compared gene expression in gut epithelial cells in three-day-old mice with that in adult mice, and found that the gene encoding TLR5 is highly expressed in the infant mice. [...]in the context of the gut microbes and the stage of postnatal development that they studied, Fulde and colleagues show not only that TLR5-deficient animals develop an abnormal gut microbial community, but also that the presence of TLR5 in gut cells is sufficient to drive the community towards a more normal composition...
  • Identifier: E-ISSN: 1476-4687 ; DOI: 10.1038/d41586-018-05861-z

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