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Urochordate Ascidians Possess a Single Isoform of Aurora Kinase That Localizes to the Midbody via TPX2 in Eggs and Cleavage Stage Embryos

PLoS One, Sep 2012, Vol.7(9), p.e45431 [Peer Reviewed Journal]

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  • Title:
    Urochordate Ascidians Possess a Single Isoform of Aurora Kinase That Localizes to the Midbody via TPX2 in Eggs and Cleavage Stage Embryos
  • Author: Hebras, Celine ; Mcdougall, Alex
  • Found In: PLoS One, Sep 2012, Vol.7(9), p.e45431 [Peer Reviewed Journal]
  • Subjects: France ; Drosophila ; Embryos ; Chromosomes ; Binding ; Pharmacology ; Aurora Kinase ; Eggs ; Vertebrates ; Eukaryotes ; Localization ; Embryos ; Localization ; Cleavage ; Kinases ; Cell Cycle ; Proteins ; Embryos ; Proteins ; Chromosomes
  • Language: English
  • Description: Aurora kinases are key proteins found throughout the eukaryotes that control mitotic progression. Vertebrate Aurora-A and B kinases are thought to have evolved from a single Aurora-kinase isoform closest to that found in present day urochordates. In urochordate ascidians Aurora binds both TPX2 (a vertebrate AURKA partner) and INCENP (a vertebrate AURKB partner) and localizes to centrosomes and spindle microtubules as well as chromosomes and midbody during both meiosis and mitosis. Ascidian Aurora also displays this localization pattern during mitosis in echinoderms, strengthening the idea that non-vertebrate deuterostomes such as the urochordates and echinoderms possess a single form of Aurora kinase that has properties of vertebrate Aurora-kinase A and B. In the ascidian, TPX2 localizes to the centrosome and the spindle poles also as in vertebrates. However, we were surprised to find that TPX2 also localized strongly to the midbody in ascidian eggs and embryos. We thus examined more closely...
  • Identifier: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0045431

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