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Origin and Diversification of TRIM Ubiquitin Ligases

PLoS One, Nov 2012, Vol.7(11), p.e50030 [Peer Reviewed Journal]

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  • Title:
    Origin and Diversification of TRIM Ubiquitin Ligases
  • Author: Marín, Ignacio
  • Found In: PLoS One, Nov 2012, Vol.7(11), p.e50030 [Peer Reviewed Journal]
  • Subjects: Signal Transduction ; Proteins ; Gene Expression ; Evolution ; Phylogenetics ; Immunity ; Bioinformatics ; Animals ; Cancer ; Mutation ; Fungi ; Tumor Necrosis Factor-Tnf ; Vertebrates ; Evolution ; Eukaryotes ; Animals ; Protein Structure ; Ubiquitin ; Proteins ; Kinases
  • Language: English
  • Description: Most proteins of the TRIM family (also known as RBCC family) are ubiquitin ligases that share a peculiar protein structure, characterized by including an N-terminal RING finger domain closely followed by one or two B-boxes. Additional protein domains found at their C termini have been used to classify TRIM proteins into classes. TRIMs are involved in multiple cellular processes and many of them are essential components of the innate immunity system of animal species. In humans, it has been shown that mutations in several TRIM-encoding genes lead to diverse genetic diseases and contribute to several types of cancer. They had been hitherto detected only in animals. In this work, by comprehensively analyzing the available diversity of TRIM and TRIM-like protein sequences and evaluating their evolutionary patterns, an improved classification of the TRIM family is obtained. Members of one of the TRIM subfamilies defined, called Subfamily A, turn to be present not only in animals, but also in...
  • Identifier: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0050030

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