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Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody

Proceedings of the National Academy of Sciences of the United States of America, 2017, Vol.115(1) [Peer Reviewed Journal]

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  • Title:
    Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody
  • Author: Raymond, Donald D.; Bajic, Goran; Ferdman, Jack; Suphaphiphat, Pirada; Settembre, Ethan C.; Moody, M. Anthony; Schmidt, Aaron G.; Harrison, Stephen C.
  • Found In: Proceedings of the National Academy of Sciences of the United States of America, 2017, Vol.115(1) [Peer Reviewed Journal]
  • Subjects: Applied Life Sciences
  • Language: English
  • Description: Antigenic variation requires frequent revision of annual influenza vaccines. Next-generation vaccine design strategies aim to elicit a broader immunity by directing the human immune response toward conserved sites on the principal viral surface protein, the hemagglutinin (HA). We describe a group of antibodies that recognize a hitherto unappreciated, conserved site on the HA of H1 subtype influenza viruses. Mutations in that site, which required a change in the H1 component of the 2017 vaccine, had not previously “taken over” among circulating H1 viruses. Our results encourage vaccine design strategies that resurface a protein to focus the immune response on a specific region. Journal Article.
  • Identifier: ISSN: 0027-8424 ; DOI: 10.1073/pnas.1715471115

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