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Supramolecular chemistry targeting proteins

Journal of the American Chemical Society, 2017, Vol.139(40), pp.13960-13968 [Peer Reviewed Journal]

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  • Title:
    Supramolecular chemistry targeting proteins
  • Author: van Dun, S. ; Ottmann, C. ; Milroy, L.-G. ; Brunsveld, L.
  • Contributor: Chemical Biology ; Institute for Complex Molecular Systems
  • Found In: Journal of the American Chemical Society, 2017, Vol.139(40), pp.13960-13968 [Peer Reviewed Journal]
  • Subjects: Journal Article ; Journal Article ; Research Support, Non-U.S. Gov'T
  • Language: English
  • Description: The specific recognition of protein surface elements is a fundamental challenge in the life sciences. New developments in this field will form the basis of advanced therapeutic approaches and lead to applications such as sensors, affinity tags, immobilization techniques, and protein-based materials. Synthetic supramolecular molecules and materials are creating new opportunities for protein recognition that are orthogonal to classical small molecule and protein-based approaches. As outlined here, their unique molecular features enable the recognition of amino acids, peptides, and even whole protein surfaces, which can be applied to the modulation and assembly of proteins. We believe that structural insights into these processes are of great value for the further development of this field and have therefore focused this Perspective on contributions that provide such structural data.
  • Identifier: ISSN: ; ISSN: 0002-7863

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