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Providing Correct Estimates of Biological Variation-Not an Easy Task. The Example of S100-β Protein and Neuron-Specific Enolase

Clinical chemistry, October 2018, Vol.64(10), pp.1537-1539 [Peer Reviewed Journal]

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  • Title:
    Providing Correct Estimates of Biological Variation-Not an Easy Task. The Example of S100-β Protein and Neuron-Specific Enolase
  • Author: Carobene, Anna ; Guerra, Elena ; Locatelli, Massimo ; Ceriotti, Ferruccio ; Sandberg, Sverre ; Fernandez-Calle, Pilar ; Coşkun, Abdurrahman ; Aarsand, Aasne K
  • Found In: Clinical chemistry, October 2018, Vol.64(10), pp.1537-1539 [Peer Reviewed Journal]
  • Subjects: Biological Variation, Population ; Phosphopyruvate Hydratase -- Blood ; S100 Calcium Binding Protein Beta Subunit -- Blood
  • Language: English
  • Description: (2), but these studies also would receive BIVAC grade C. When performing BV studies, it is important that studies include all elements that may affect veracity and utility of the data, and the studies must also have adequate power, which depends on the study design and the ratio between CVA and CVI (3) The highly powered and fully BIVAC-compliant EuBIVAS delivers considerably lower RCVs and stricter analytical performance specifications than those based on non-BIVAC-compliant studies (Table 1), with clinical implications both for monitoring patients and ensuring that analytical methods are fit for purpose. Author Contributions: All authors confirmed they have contributed to the intellectual content of this paper and have met the following 4 requirements: (a) significant contributions to the conception and design, acquisition ofdata, or analysis and interpretation ofdata; (b) draftingor revising the article for intellectual content; (c) final approval ofthe published article; and (d) agreement...
  • Identifier: E-ISSN: 1530-8561 ; PMID: 30068693 Version:1 ; DOI: 10.1373/clinchem.2018.292169

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