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Role of A-Kinase anchor protein (AKAP4) in growth and survival of ovarian cancer cells

Oncotarget, 08 August 2017, Vol.8(32), pp.53124-53136 [Peer Reviewed Journal]

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  • Title:
    Role of A-Kinase anchor protein (AKAP4) in growth and survival of ovarian cancer cells
  • Author: Kumar, Vikash ; Jagadish, Nirmala ; Suri, Anil
  • Found In: Oncotarget, 08 August 2017, Vol.8(32), pp.53124-53136 [Peer Reviewed Journal]
  • Subjects: Akap4 ; Pka ; Apoptosis ; Reactive Oxygen Species ; S-Phase Arrest
  • Language: English
  • Description: Ovarian cancer represents one of the most common malignancies among women with very high mortality rate worldwide. A-kinase anchor protein 4 (AKAP4), a unique cancer testis (CT) antigen has been shown to be associated with various malignant properties of cancer cells. However, its involvement in various molecular pathways in ovarian cancer remains unknown. In present investigation, employing gene silencing approach, we examined the role of AKAP4 in cell cycle, apoptosis and epithelial-mesenchymal transition (EMT). Further, we also investigated the effect of ablation of AKAP4 on tumor growth in SCID mice ovarian cancer xenograft mouse model. Our results showed that ablation of AKAP4 resulted in increased reactive oxygen species (ROS) generation, DNA damage, cell cycle arrest and apoptosis in ovarian cancer cells. AKAP4 knockdown lead to degradation of protien kinase A (PKA) which was rescued by proteosome inhibitor MG-132. ROS quencher N-acetyl cysteine (NAC) treatment rescued cell cycle...
  • Identifier: E-ISSN: 1949-2553 ; PMID: 28881798 Version:1 ; DOI: 10.18632/oncotarget.18163

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