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Electronic control of gene expression and cell behaviour in Escherichia coli through redox signalling

Nature communications, 17 January 2017, Vol.8, pp.14030 [Peer Reviewed Journal]

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  • Title:
    Electronic control of gene expression and cell behaviour in Escherichia coli through redox signalling
  • Author: Tschirhart, Tanya ; Kim, Eunkyoung ; Mckay, Ryan ; Ueda, Hana ; Wu, Hsuan-Chen ; Pottash, Alex Eli ; Zargar, Amin ; Negrete, Alejandro ; Shiloach, Joseph ; Payne, Gregory F ; Bentley, William E
  • Found In: Nature communications, 17 January 2017, Vol.8, pp.14030 [Peer Reviewed Journal]
  • Subjects: Gene Expression Regulation, Bacterial ; Electronics -- Instrumentation ; Escherichia Coli -- Metabolism
  • Language: English
  • Description: The ability to interconvert information between electronic and ionic modalities has transformed our ability to record and actuate biological function. Synthetic biology offers the potential to expand communication 'bandwidth' by using biomolecules and providing electrochemical access to redox-based cell signals and behaviours. While engineered cells have transmitted molecular information to electronic devices, the potential for bidirectional communication stands largely untapped. Here we present a simple electrogenetic device that uses redox biomolecules to carry electronic information to engineered bacterial cells in order to control transcription from a simple synthetic gene circuit. Electronic actuation of the native transcriptional regulator SoxR and transcription from the PsoxS promoter allows cell response that is quick, reversible and dependent on the amplitude and frequency of the imposed electronic signals. Further, induction of bacterial motility and population based cell-to-cell...
  • Identifier: E-ISSN: 2041-1723 ; PMID: 28094788 Version:1 ; DOI: 10.1038/ncomms14030

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