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Age-Dependent Changes in Geometry, Tissue Composition and Mechanical Properties of Fetal to Adult Cryopreserved Human Heart Valves

PloS one, 2016, Vol.11(2), pp.e0149020 [Peer Reviewed Journal]

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  • Title:
    Age-Dependent Changes in Geometry, Tissue Composition and Mechanical Properties of Fetal to Adult Cryopreserved Human Heart Valves
  • Author: Van Geemen, Daphne ; Soares, Ana L F ; Oomen, Pim J A ; Driessen-Mol, Anita ; Janssen-Van Den Broek, Marloes W J T ; Van Den Bogaerdt, Antoon J ; Bogers, Ad J J C ; Goumans, Marie-José T H ; Baaijens, Frank P T ; Bouten, Carlijn V C
  • Found In: PloS one, 2016, Vol.11(2), pp.e0149020 [Peer Reviewed Journal]
  • Subjects: Cryopreservation ; Heart Valves -- Anatomy & Histology
  • Language: English
  • Description: There is limited information about age-specific structural and functional properties of human heart valves, while this information is key to the development and evaluation of living valve replacements for pediatric and adolescent patients. Here, we present an extended data set of structure-function properties of cryopreserved human pulmonary and aortic heart valves, providing age-specific information for living valve replacements. Tissue composition, morphology, mechanical properties, and maturation of leaflets from 16 pairs of structurally unaffected aortic and pulmonary valves of human donors (fetal-53 years) were analyzed. Interestingly, no major differences were observed between the aortic and pulmonary valves. Valve annulus and leaflet dimensions increase throughout life. The typical three-layered leaflet structure is present before birth, but becomes more distinct with age. After birth, cell numbers decrease rapidly, while remaining cells obtain a quiescent phenotype and reside in...
  • Identifier: E-ISSN: 1932-6203 ; PMID: 26867221 Version:1 ; DOI: 10.1371/journal.pone.0149020

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