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Frequent loss of heterozygosity at 8p22 chromosomal region in diffuse type of gastric cancer

World journal of gastroenterology, 28 June 2007, Vol.13(24), pp.3354-8 [Peer Reviewed Journal]

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  • Title:
    Frequent loss of heterozygosity at 8p22 chromosomal region in diffuse type of gastric cancer
  • Author: Hosseini, Hedayat Allah ; Ahani, Ali ; Galehdari, Hamid ; Froughmand, Ali Mohammad ; Hosseini, Masoud ; Masjedizadeh, Abdolrahim ; Zali, Mohammad Reza
  • Found In: World journal of gastroenterology, 28 June 2007, Vol.13(24), pp.3354-8 [Peer Reviewed Journal]
  • Subjects: Chromosomes, Human, Pair 8 ; Loss of Heterozygosity ; Stomach Neoplasms -- Genetics
  • Language: English
  • Description: To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer. To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of mentioned region, to perform a high-resolution analysis of allele loss in 42 cases of late diffuse gastric adenocarcinoma. Six of these STS makers: D8S1149, D8S1645, D8S1643, D8S1508, D8S1591, and D8S1145 showed 36%, 28%, 37%, 41%, 44% and 53% LOH, respectively. A critical region of loss, close to the NAT2 locus and relatively far from FEZ1 gene currently postulated as tumor suppressor gene in this region.
  • Identifier: ISSN: 1007-9327 ; PMID: 17659675 Version:1

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