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Abietane diterpenoids synthesized by suspension-cultured cells of Cephalotaxus fortunei

Phytochemistry Letters, 2011, Vol.4(1), pp.52-55 [Peer Reviewed Journal]

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  • Title:
    Abietane diterpenoids synthesized by suspension-cultured cells of Cephalotaxus fortunei
  • Author: Xu, Xiao-Hui ; Zhang, Wei ; Cao, Xu-Peng ; Xue, Song
  • Found In: Phytochemistry Letters, 2011, Vol.4(1), pp.52-55 [Peer Reviewed Journal]
  • Subjects: Abietane Diterpenoids ; Elicitation ; In Situ Product Removal ; Cephalotaxus Fortunei ; Cell Suspension Culture ; Botany
  • Language: English
  • Description: Along with six known abietane diterpenoids, but new to the plant, one new compound was produced by the suspension-cultured cells by complementing an elicitation strategy with an in situ product removal strategy. Based on the results of spectrometric analysis, the structure of the new compound was determined to be 20(10→5)-abeo-4,5-seco-5(10),6,8,11,13-abietapentaene-3-one ( ). ▶ Cell cultures of were manipulated to produce secondary metabolites. ▶ Seven abietane diterpenoids including six known and one new were produced. ▶ We report the isolation and identification of these seven abietane diterpenoids. ▶ Diterpenoids have been isolated and identified from for the first time. ▶ The strategy of elicitation integrated with in situ product removal was effective. Cell suspension cultures of were manipulated to produce secondary metabolites of pharmaceutical interest. Seven abietane diterpenoids (six known and one new) were produced by the suspension-cultured cells by complementing an elicitation strategy with an in situ product removal strategy. Based on the results of spectrometric analysis, the structure of the new compound was determined to be 20(10→5)-abeo-4,5-seco-5(10),6,8,11,13-abietapentaene-3-one ( ). The six known compounds were identified as 12-hydroxyabieta-6,8,11,13-tetraene-3-one ( ), abieta-8,11,13-triene-3β,12-diol (hinokiol) ( ), abietatriene-3β-ol ( ), 11,12-dihydroxy-8,11,13-abietatriene-3,7-dione ( ), 11-hydroxy-12-methoxyabieta-8,11,13-triene-3,7-dione ( ), and 3β,11-dihydroxy-12-methoxyabieta-8,11,13-triene-7-one ( ). This is the first time that diterpenoids have been isolated and identified from this pharmaceutically important plant. These results suggest that the strategies we applied were effective methods for synthesizing abietane diterpenoids via a suspension culture of cells.
  • Identifier: ISSN: 1874-3900 ; E-ISSN: 1876-7486 ; DOI: 10.1016/j.phytol.2010.12.003

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