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The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7

Hemijska Industrija, 01 January 2017, Vol.71(6), pp.487-494 [Peer Reviewed Journal]

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  • Title:
    The use of salicylaldehyde derivatives as a nitrogen source for antibiotic production by Streptomyces hygroscopicus CH-7
  • Author: Konstantinović Sandra S ; Zlatković Milica Z ; Ćirić Jovan T ; Ilić Slavica B ; Gojgić-Cvijović Gordana D ; Veljković Vlada B
  • Found In: Hemijska Industrija, 01 January 2017, Vol.71(6), pp.487-494 [Peer Reviewed Journal]
  • Subjects: Glycerol ; Salicylaldehyde ; Streptomyces ; Antibiotic ; Morphology ; Economics
  • Language: English
  • Description: In the present work, four derivatives of salicylaldehyde (salicylaldehyde-hydrazone, phenylhydrazone, semicarbazone and thiosemicarbazone) were synthesized using both conventional (95% ethanol) and green (crude glycerol from biodiesel production) solvents. The obtained compounds were identified by elemental microanalysis, as well as FTIR, UV/Vis and 1H-NMR spectroscopic methods. Yields of 93–98% of the compounds in crude glycerol were achieved within 10–25 min. The derivatives of salicylaldehyde and crude glycerol were used as a nitrogen and carbon source, respectively, in the medium for antibiotic (hexaene H-85 and azalomycine B) production by Streptomyces hygroscopicus CH-7. The highest concentrations of hexaene H-85 and azalomycine B were achieved in the medium containing salicylaldehyde-thiosemicarbazone (198 and 69 μg/cm3, respectively). Derivatives of salicylaldehyde also impacted the strain morphology. In the media with salicylaldehyde- phenylhydrazone and salicylaldehyde-thiosemicarbazone, S. hygroscopicus CH-7 grew like large dispersive pellets with long twisted filaments that produced the highest yield of the antibiotics. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. III 45001]
  • Identifier: ISSN: 0367-598X ; E-ISSN: 2217-7426 ; DOI: 10.2298/HEMIND170124011K

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