skip to main content
Show Results with:

C-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes

Pallet, Nicolas; Thervet, Eric; Anglicheau, Dany

Journal of transplantation. Volume 2012 (2012) -- Hindawi

Online access

  • Title:
    C-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes
  • Author: Pallet, Nicolas;
    Thervet, Eric;
    Anglicheau, Dany;
    Kaplan, Bruce
  • Found In: Journal of transplantation. Volume 2012 (2012)
  • Journal Title: Journal of transplantation
  • Subjects: Transplantation of organs, tissues, etc--Periodicals; Dewey: 617.95405
  • Rights: legaldeposit
  • Publication Details: Hindawi
  • Abstract: Abstract :

    Tubular epithelial cells play a central role in the pathogenesis of chronic nephropathies. Previous toxicogenomic studies have demonstrated that cyclosporine- (CsA-) induced epithelial phenotypic changes (EPCs) are reminiscent of an incomplete epithelial to mesenchymal transition (EMT) in a TGF- β -independent manner. Furthermore, we identified endoplasmic reticulum (ER) stress as a potential mechanism that may participate in the modulation of tubular cell plasticity during CsA exposure. Because c-jun-N-terminal kinase (JNK), which is activated during ER stress, is implicated in kidney fibrogenesis, we undertook the current study to identify the role of JNK signaling in EPCs induced by CsA. In primary cultures of human renal epithelial cells, CsA activates JNK signaling, and the treatment with a JNK inhibitor reduces the occurrence of cell shape changes, E-cadherin downregulation, cell migration, and Snail-1 expression. Our results suggest that CsA activates JNK signaling, which, in turn, may participate in the morphological alterations through the regulation of Snail-1 expression.


  • Identifier: System Number: LDEAvdc_100085043379.0x000001; Journal ISSN: 2090-0007; 10.1155/2012/348604
  • Publication Date: 2012
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

Searching Remote Databases, Please Wait