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Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway

Lee, Sang-Hoon et al.

Journal of chemistry. Volume 2016 (2016) -- Hindawi

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  • Title:
    Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway
  • Author: Lee, Sang-Hoon;
    Eom, Sung-Hwan;
    Yoon, Na-Young;
    Kim, Moon-Moo;
    Li, Yong-Xin;
    Ha, Sang Keun;
    Kim, Se-Kwon;
    Valentao, Patricia
  • Found In: Journal of chemistry. Volume 2016 (2016)
  • Journal Title: Journal of chemistry
  • Subjects: Chemistry--Periodicals; Dewey: 540.5
  • Rights: legaldeposit
  • Publication Details: Hindawi
  • Abstract: Abstract :

    Fucofuroeckol-A (FF) isolated from an edible perennial brown seaweed Eisenia bicyclis was shown to be potent anti-inflammatory agents. FF suppressed the production of nitric oxide (NO) and prostaglandin E2(PGE2) and the expression of inducible nitric oxide synthase and cyclooxygenase-2 dose dependently in lipopolysaccharide- (LPS-) induced RAW 264.7 mouse macrophages. An enzyme-linked immunosorbent assay and cytometric bead array assay demonstrated that FF significantly reduced the production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor- α, and that of the monocyte chemoattractant protein-1. Moreover, FF reduced the activation of nuclear factor κ B (NF- κ B) and mitogen-activated protein kinases (MAPKs). These results strongly suggest that the inhibitory effects of fucofuroeckol-A from E. bicyclis on LPS-induced NO and PGE2production might be due to the suppression of the NF- κ B and MAPK signaling pathway.


  • Identifier: System Number: LDEAvdc_100083799862.0x000001; Journal ISSN: 2090-9063; 10.1155/2016/6509212
  • Publication Date: 2016
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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