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Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes

Admoni, Sharon Nina et al.

Diabetes & vascular disease research: official journal of the International Society of Diabetes and Vascular Disease. Volume 16:Number 3 (2019, May); pp 297-299 -- Sage Publications

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  • Title:
    Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes
  • Author: Admoni, Sharon Nina;
    Santos-Bezerra, Daniele Pereira;
    Perez, Ricardo Vesoni;
    Patente, Thiago Andrade;
    Monteiro, Maria Beatriz;
    Cavaleiro, Ana Mercedes;
    Parisi, Maria Candida;
    Moura Neto, Arnaldo;
    Pavin, Elizabeth Joao;
    Queiroz, Marcia Silva;
    Nery, Marcia;
    Correa-Giannella, Maria Lucia
  • Found In: Diabetes & vascular disease research: official journal of the International Society of Diabetes and Vascular Disease. Volume 16:Number 3 (2019, May); pp 297-299
  • Journal Title: Diabetes & vascular disease research: official journal of the International Society of Diabetes and Vascular Disease
  • Subjects: Diabetic angiopathies--Periodicals; Cardiovascular autonomic neuropathy--oxidative stress--type 1 diabetes--glutathione peroxidase 4; Dewey: 616.462005
  • Rights: legaldeposit
  • Publication Details: Sage Publications
  • Abstract:

    Cardiac autonomic neuropathy is a neglected diabetic chronic complication for which genetic predictors are rarely reported. Oxidative stress is implicated in the pathogenesis of microvascular complications, and glutathione peroxidase 4 is involved in the detoxification of peroxides and of reactive oxygen species. Thus, the association of a functional variant in the gene encoding glutathione peroxidase 4 (rs713041) with this diabetic complication was investigated in 341 individuals with type 1 diabetes evaluated for cardiac autonomic neuropathy status (61.7% women, 34 [27–42] years old; diabetes duration: 21 [15–27] years; HbA1c: 8.3% [7.4–9.4]; as median [interquartile interval]). Cardiac autonomic neuropathy was present in 29% of the participants. There was an inverse association of the minor T allele of rs713041 with cardiac autonomic neuropathy (odds ratio = 0.39; 95% confidence interval = 0.17–0.90; p   =  0.0271) after adjustment for potential confounders. The functional glutathione peroxidase 4 variant rs713041 modulated the risk for cardiac autonomic neuropathy in the studied population with type 1 diabetes.


  • Identifier: System Number: LDEAvdc_100083436609.0x000001; Journal ISSN: 1479-1641; 10.1177/1479164118820641
  • Publication Date: 2019
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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