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Frontispiece: Synthesis of Highly Substituted 1, 2‐Diazetidin‐3‐ones, Small‐Ring Scaffolds for Drug Discovery

Santos, Marilia S. et al.

Chemistry: a European journal. Volume 24:Issue 33 (2018); pp n/a-n/a -- Wiley-VCH Verlag

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  • Title:
    Frontispiece: Synthesis of Highly Substituted 1, 2‐Diazetidin‐3‐ones, Small‐Ring Scaffolds for Drug Discovery
  • Author: Santos, Marilia S.;
    Nortcliffe, Andrew;
    Lewis, William;
    Bradshaw, Tracey D.;
    Moody, Christopher J.
  • Found In: Chemistry: a European journal. Volume 24:Issue 33 (2018); pp n/a-n/a
  • Journal Title: Chemistry: a European journal
  • Subjects: Chemistry--Periodicals; 4-membered rings--carbene insertion--drug discovery--heterocycles--lead-oriented synthesis; Dewey: 540
  • Rights: legaldeposit
  • Publication Details: Wiley-VCH Verlag
  • Abstract: Abstract :

    1, 2‐Diazetidin‐3‐ones remain an under‐investigatedsmall‐ring heterocycle. Nevertheless their diverse structures offer the potential to explore chemical space as illustrated by the principal moments of inertia "triangle" in rod‐like (rocket), sphere‐like (planet) and disc‐like (flying saucer) regions. Inspired by the unexpected three‐dimensionality of substituted 1, 2‐diazetidin‐3‐ones, the synthesis and functionalization of a range of these strained four‐membered rings are reported; for more details, see Full Paper by C. J. Moody et al. onpage 8325 ff.


  • Identifier: System Number: LDEAvdc_100076477755.0x000001; Journal ISSN: 0947-6539; 10.1002/chem.201883365
  • Publication Date: 2018
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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