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Calcium signaling as a mediator of cell energy demand and a trigger to cell death

Bhosale, Gauri et al.

Annals of the New York Academy of Sciences. Volume 1350 (2015); pp 107-116 -- [Blackwell Publishing]

Online access

  • Title:
    Calcium signaling as a mediator of cell energy demand and a trigger to cell death
  • Author: Bhosale, Gauri;
    Sharpe, Jenny A.;
    Sundier, Stephanie Y.;
    Duchen, Michael R.
  • Found In: Annals of the New York Academy of Sciences. Volume 1350 (2015); pp 107-116
  • Journal Title: Annals of the New York Academy of Sciences
  • Subjects: Medical sciences--Periodicals; Medicine--Periodicals; Science--Periodicals; calcium signaling--mitochondrial calcium uptake--cell death--MICU1--mitochondrial permeability transition pore--ischemia/reperfusion injury; Dewey: 610
  • Rights: legaldeposit
  • Publication Details: [Blackwell Publishing]
  • Abstract: Abstract :

    Calcium signaling is pivotal to a host of physiological pathways. A rise in calcium concentration almost invariably signals an increased cellular energy demand. Consistent with this, calcium signals mediate a number of pathways that together serve to balance energy supply and demand. In pathological states, calcium signals can precipitate mitochondrial injury and cell death, especially when coupled to energy depletion and oxidative or nitrosative stress. This review explores the mechanisms that couple cell signaling pathways to metabolic regulation or to cell death. The significance of these pathways is exemplified by pathological case studies, such as those showing loss of mitochondrial calcium uptake 1 in patients and ischemia/reperfusion injury.


  • Identifier: System Number: LDEAvdc_100072999102.0x000001; Journal ISSN: 0077-8923; 10.1111/nyas.12885
  • Publication Date: 2015
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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