skip to main content
Show Results with:

A substrate localization model for the selective regulation of TORC1 downstream pathways

Takeda, Eigo; Matsuura, Akira

Communicative & integrative biology. Volume 11:Issue 2 (2018); pp 1-4 -- Taylor & Francis

Online access

  • Title:
    A substrate localization model for the selective regulation of TORC1 downstream pathways
  • Author: Takeda, Eigo;
    Matsuura, Akira
  • Found In: Communicative & integrative biology. Volume 11:Issue 2 (2018); pp 1-4
  • Journal Title: Communicative & integrative biology
  • Subjects: Biology--Periodicals; Molecular biology--Periodicals; TORC1--signal transduction--phosphoinositide--vacuoles--yeast; Dewey: 579.05
  • Rights: legaldeposit
  • Publication Details: Taylor & Francis
  • Abstract: ABSTRACT:

    Target of rapamycin complex 1 (TORC1) is a protein kinase complex conserved in eukaryotes that coordinates diverse cellular processes critical for cell growth to environmental conditions. Previous studies have shown that TORC1 is localized mainly in the lysosome/vacuoles, and its localization is important for signaling to downstream pathways. We recently demonstrated that signaling to Sch9, an S6K-related substrate of TORC1 in budding yeast, was selectively suppressed upon oxidative stress, which was mediated by the delocalization of phosphatidylinositol 3, 5-bisphosphate (PI[3, 5]P2) from vacuolar membranes following stress. We propose that TORC1 downstream pathways can be regulated separately via the modulation of organelle localization of a specific target protein.


  • Identifier: System Number: LDEAvdc_100067477171.0x000001; Journal ISSN: 1942-0889; 10.1080/19420889.2018.1475830
  • Publication Date: 2018
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

Searching Remote Databases, Please Wait