skip to main content
Show Results with:

Converging cellular themes for the hereditary spastic paraplegias

Blackstone, Craig

Current opinion in neurobiology. Volume 51 (2018); pp 139-146 -- Elsevier

Online access

  • Title:
    Converging cellular themes for the hereditary spastic paraplegias
  • Author: Blackstone, Craig
  • Found In: Current opinion in neurobiology. Volume 51 (2018); pp 139-146
  • Journal Title: Current opinion in neurobiology
  • Subjects: Neurobiology--Periodicals; Dewey: 573.8
  • Rights: legaldeposit
  • Publication Details: Elsevier
  • Abstract: Abstract :

    Hereditary spastic paraplegias (HSPs) are neurologic disorders characterized by prominent lower-extremity spasticity, resulting from a length-dependent axonopathy of corticospinal upper motor neurons. They are among the most genetically-diverse neurologic disorders, with >80 distinct genetic loci and over 60 identified genes. Studies investigating the molecular pathogenesis underlying HSPs have emphasized the importance of converging cellular pathogenic themes in the most common forms of HSP, providing compelling targets for therapy. Most notably, these include organelle shaping and biogenesis as well as membrane and cargo trafficking.


  • Identifier: System Number: LDEAvdc_100067342823.0x000001; Journal ISSN: 0959-4388; 10.1016/j.conb.2018.04.025
  • Publication Date: 2018
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

Searching Remote Databases, Please Wait