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Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation

Li, Yongsheng et al.

Trends in biochemical sciences. Volume 43:Issue 8 (2018, August); pp 576-592 -- Elsevier

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  • Title:
    Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation
  • Author: Li, Yongsheng;
    McGrail, Daniel J.;
    Xu, Juan;
    Mills, Gordon B.;
    Sahni, Nidhi;
    Yi, Song
  • Found In: Trends in biochemical sciences. Volume 43:Issue 8 (2018, August); pp 576-592
  • Journal Title: Trends in biochemical sciences
  • Subjects: Biochemistry--Periodicals; gene regulatory networks--alternative splicing--genetic and epigenetic--molecular regulators--computational and experimental methods; Dewey: 572
  • Rights: legaldeposit
  • Publication Details: Elsevier
  • Abstract: Abstract :

    Gene regulatory networks underlie biological function and cellular physiology. Alternative splicing (AS) is a fundamental step in gene regulatory networks and plays a key role in development and disease. In addition to the identification of aberrant AS events, an increasing number of studies are focusing on molecular determinants of AS, including genetic and epigenetic regulators. We review here recent efforts to identify various deregulated AS events as well as their molecular determinants that alter biological functions, and discuss clinical features of AS and their druggable potential.

    Highlights:

    AS contributes to widespread structural transcript variation and proteome diversity.

    Studies in various diseases have shown that AS plays crucial roles in different aspects of etiology, suggesting that AS isoforms could potentially serve as therapeutic targets.

    Various types of genetic and epigenetic regulators of AS have been revealed.

    A combination of computational and experimental approaches is instrumental in identifying AS events as well as potential regulators.


  • Identifier: System Number: LDEAvdc_100067196210.0x000001; Journal ISSN: 0968-0004; 10.1016/j.tibs.2018.05.002
  • Publication Date: 2018
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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