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C‐Reactive protein and progression of vision loss in retinitis pigmentosa

Murakami, Yusuke et al.

Acta ophthalmologica. Volume 96:Issue 2 (2018); pp e174-e179 -- John Wiley & Sons Ltd

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  • Title:
    C‐Reactive protein and progression of vision loss in retinitis pigmentosa
  • Author: Murakami, Yusuke;
    Ikeda, Yasuhiro;
    Nakatake, Shunji;
    Fujiwara, Kohta;
    Tachibana, Takashi;
    Yoshida, Noriko;
    Notomi, Shoji;
    Hisatomi, Toshio;
    Yoshida, Shigeo;
    Ishibashi, Tatsuro;
    Sonoda, Koh‐Hei
  • Found In: Acta ophthalmologica. Volume 96:Issue 2 (2018); pp e174-e179
  • Journal Title: Acta ophthalmologica
  • Subjects: Ophthalmology--Periodicals; high sensitive c‐reactive protein--inflammation--progression--retinitis pigmentosa; Dewey: 617.7005
  • Rights: legaldeposit
  • Publication Details: John Wiley & Sons Ltd
  • Abstract: Abstract: Purpose:

    Chronic inflammation is involved in retinitis pigmentosa (RP). We demonstrated previously that intraocular inflammatory levels, as measured by slit‐lamp ophthalmoscopy or laser flare photometry, are inversely correlated with central visual function in patients with RP. Here, we investigated the relationship between serum high‐sensitivity C‐reactive protein (hs‐CRP) and visual parameters in RP.

    Methods:

    We studied 58 consecutive typical patients with RP <40 years old and 29 age‐ and gender‐matched controls. High‐sensitivity C‐reactive protein (hs‐CRP) was detected by immunoturbidimetry. The relationships between hs‐CRP and visual parameters including best‐corrected visual acuity (BCVA), mean deviation (MD) of static perimetry tests (Humphrey Field Analyzer, the central 10‐2 programme) and VA changes over the prior 5 years and MD changes over the prior 3 years were analysed in the patients with RP.

    Results:

    The serum hs‐CRP levels of the patients with RP were significantly higher than those of the controls (0.06 ± 0.08 versus 0.03 ± 0.04 mg/dl, p = 0.0119). In the patients with RP, there was no correlation of hs‐CRP with cross‐sectionally assessed VA or MD, but the baseline hs‐CRP was significantly correlated with the MD deterioration ( r  = −0.4073, p = 0.0314).

    Conclusion:

    The average serum hs‐CRP was significantly increased in the patients with RP, and higher hs‐CRP was associated with faster deterioration of central visual function. These results suggest that the systemic inflammatory profile is altered and may be associated with disease progression in RP.


  • Identifier: System Number: LDEAvdc_100057271727.0x000001; Journal ISSN: 1755-375X; 10.1111/aos.13502
  • Publication Date: 2018
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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