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Targeting Akt in cell transfer immunotherapy for cancer

Crompton, Joseph G; Sukumar, Madhusudhanan; Restifo, Nicholas P

Oncoimmunology. Volume 5:Number 9 (2016) -- Taylor & Francis

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  • Title:
    Targeting Akt in cell transfer immunotherapy for cancer
  • Author: Crompton, Joseph G;
    Sukumar, Madhusudhanan;
    Restifo, Nicholas P
  • Found In: Oncoimmunology. Volume 5:Number 9 (2016)
  • Journal Title: Oncoimmunology
  • Subjects: Immunotherapy--Periodicals; Neoplasms--therapy--Periodicals; Tumors--Immunological aspects--Periodicals; Akt inhibition--cell-based immunotherapy--immunometabolism; Dewey: 616.994
  • Rights: legaldeposit
  • Publication Details: Taylor & Francis
  • Abstract: Abstract :

    Pharmacologic inhibitors of the serine/threonine kinase Akt, initially aimed at deranged oncogenic pathways in tumors, have recently been shown to act as immunomodulators that markedly enhance the antitumor properties of T cells. Repurposing Akt inhibitors to improve antitumor immunity may be viewed as a manifestation of a larger paradigmatic shift in which hallmark characteristics of cancer (e.g., immune evasion), rather than merely causal features (e.g., somatic mutations) can be exploited for therapeutic benefit.


  • Identifier: System Number: LDEAvdc_100052904453.0x000001; Journal ISSN: 2162-402X; 10.1080/2162402X.2015.1014776
  • Publication Date: 2016
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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