skip to main content
Show Results with:

The Association Between Glycosylation of Immunoglobulin G and Hypertension: A Multiple Ethnic Cross-Sectional Study

Wang, Youxin et al.

Medicine. Volume 95:Issue 17 (2016, April 23rd); pp e3379- -- Lippincott, Williams & Wilkins

Online access

  • Title:
    The Association Between Glycosylation of Immunoglobulin G and Hypertension: A Multiple Ethnic Cross-Sectional Study
  • Author: Wang, Youxin;
    Klarić, Lucija;
    Yu, Xinwei;
    Thaqi, Kujtim;
    Dong, Jing;
    Novokmet, Mislav;
    Wilson, Jim;
    Polasek, Ozren;
    Liu, Youqin;
    Krištić, Jasminka;
    Ge, Siqi;
    Pučić-Baković, Maja;
    Wu, Lijuan;
    Zhou, Yong;
    Ugrina, Ivo;
    Song, Manshu;
    Zhang, Jie;
    Guo, Xiuhua;
    Zeng, Qiang;
    Rudan, Igor;
    Campbell, Harry;
    Aulchenko, Yurii;
    Lauc, Gordan;
    Wang, Wei;
    Xie., Wuxiang
  • Found In: Medicine. Volume 95:Issue 17 (2016, April 23rd); pp e3379-
  • Journal Title: Medicine
  • Subjects: Médecine--Périodiques; Periodicals; Medicine--Periodicals; Geneeskunde; Medicine; Dewey: 610.5
  • Rights: legaldeposit
  • Publication Details: Lippincott, Williams & Wilkins
  • Abstract: Abstract :

    Supplemental Digital Content is available in the text

    Abstract : Abstract:

    More than half of all known proteins, and almost all membrane and extra-cellular proteins have oligosaccharide structures or glycans attached to them. Defects in glycosylation pathways are directly involved in at least 30 severe human diseases.

    A multiple center cross-sectional study (China, Croatia, and Scotland) was carried out to investigate the possible association between hypertension and IgG glycosylation. A hydrophilic interaction chromatography of fluorescently labeled glycans was used to analyze N- glycans attached to IgG in plasma samples from a total of 4757 individuals of Chinese Han, Croatian, and Scottish ethnicity.

    Five glycans (IgG with digalactosylated glycans) significantly differed in participants with prehypertension or hypertension compared to those with normal blood pressure, while additional 17 glycan traits were only significantly differed in participants with hypertension compared to those of normal blood pressure. These glycans were also significant correlated with systolic blood pressure (SBP) or diastolic blood pressure (DBP).

    The present study demonstrated for the 1st time an association between hypertension and IgG glycome composition. These findings suggest that the individual variation in N -glycosylation of IgG contributes to pathogenesis of hypertension, presumably via its effect on pro- and/or anti-inflammatory pathways.


  • Identifier: System Number: LDEAvdc_100052391968.0x000001; Journal ISSN: 0025-7974; 10.1097/MD.0000000000003379
  • Publication Date: 2016
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

Searching Remote Databases, Please Wait