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Pembrolizumab-triggered Uveitis: An Additional Surrogate Marker for Responders in Melanoma Immunotherapy?

Diem, Stefan et al.

Journal of immunotherapy: official journal of the Society for Biological Therapy. Volume 39:Issue 9 (2016, November/December) -- Lippincott Williams & Wilkins

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  • Title:
    Pembrolizumab-triggered Uveitis: An Additional Surrogate Marker for Responders in Melanoma Immunotherapy?
  • Author: Diem, Stefan;
    Keller, Fabienne;
    Rüesch, Reinhard;
    Maillard, Samia A.;
    Speiser, Daniel E.;
    Dummer, Reinhard;
    Siano, Marco;
    Urner-Bloch, Ursula;
    Goldinger, Simone M.;
    Flatz, Lukas
  • Found In: Journal of immunotherapy: official journal of the Society for Biological Therapy. Volume 39:Issue 9 (2016, November/December)
  • Journal Title: Journal of immunotherapy: official journal of the Society for Biological Therapy
  • Subjects: Neoplasms--therapy--Periodicals; Electronic journals; Immunotherapy--Periodicals; melanoma--immunotherapy--uveitis; Dewey: 615.37
  • Rights: legaldeposit
  • Publication Details: Lippincott Williams & Wilkins
  • Abstract: Abstract :

    Immunotherapy leads to significantly prolonged survival of patients with metastatic melanoma. Autoimmune side effects including colitis, dermatitis, and endocrine abnormalities are common in patients treated with ipilimumab [anti-CTLA4 (cytotoxic T-lymphocyte-associated protein 4)]. Antibodies such as pembrolizumab that interfere with the PD-1 (programmed cell death 1)/PD-L1 pathway show greater efficacy and less toxicity than ipilimumab. Here we report 2 cases of pembrolizumab-induced uveitis associated with complete or partial tumor response. We suggest that uveitis may serve as a surrogate marker for a tumor response to therapy with pembrolizumab.


  • Identifier: System Number: LDEAvdc_100049224522.0x000001; Journal ISSN: 1524-9557; 10.1097/CJI.0000000000000143
  • Publication Date: 2016
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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