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Multiple sclerosis and air pollution exposure: Mechanisms toward brain autoimmunity

Esmaeil Mousavi, Sayed et al.

Medical hypotheses. Volume 100 (2017); pp 23-30 -- Elsevier

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  • Title:
    Multiple sclerosis and air pollution exposure: Mechanisms toward brain autoimmunity
  • Author: Esmaeil Mousavi, Sayed;
    Heydarpour, Pouria;
    Reis, Jacques;
    Amiri, Masoud;
    Sahraian, Mohammad Ali
  • Found In: Medical hypotheses. Volume 100 (2017); pp 23-30
  • Journal Title: Medical hypotheses
  • Subjects: Médecine--Périodiques; Medicine--Periodicals; Medicine; Periodicals; Multiple sclerosis--Air pollution--Oxidative stress--Blood brain barrier--Neuroinflammation--Autoimmunity; Dewey: 610
  • Rights: legaldeposit
  • Publication Details: Elsevier
  • Abstract: Abstract:

    The association between neurodegenerative diseases and environmental exposures, in particular air pollution, has been noticed in the last two decades, but the importance of this environmental factor in multiple sclerosis (MS) pathogenesis has not been considered extensively. However, recent evidence suggests that major mechanisms involved in MS pathogenesis, such as inflammatory factors expression, free radicals overproduction, the blood brain barrier (BBB) breakdown, neuroinflammation, vitamin D deficiency and mitochondrial dysfunction could also occur due to exposure to air pollutants. A prospective hypothesis is suggested here in which exposure to air pollutants may initiate destructive mechanisms inducing inflammatory-oxidative cascades, reduction of immunological self-tolerance and neurodegeneration leading to brain autoimmunity.

  • Identifier: System Number: LDEAvdc_100045443154.0x000001; Journal ISSN: 0306-9877; 10.1016/j.mehy.2017.01.003
  • Publication Date: 2017
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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