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Incidence of hepatocellular carcinoma according to hepatitis B virus genotype in Alaska Native people

Ching, Lance K. et al.

Liver international: official journal of the International Association for the Study of the Liver. Volume 36:Number 10 (2016); pp 1507-1515 -- John Wiley & Sons Ltd

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  • Title:
    Incidence of hepatocellular carcinoma according to hepatitis B virus genotype in Alaska Native people
  • Author: Ching, Lance K.;
    Gounder, Prabhu P.;
    Bulkow, Lisa;
    Spradling, Philip R.;
    Bruce, Michael G.;
    Negus, Susan;
    Snowball, Mary;
    McMahon, Brian J.
  • Found In: Liver international: official journal of the International Association for the Study of the Liver. Volume 36:Number 10 (2016); pp 1507-1515
  • Journal Title: Liver international: official journal of the International Association for the Study of the Liver
  • Subjects: Liver--Diseases--Periodicals; Liver--Periodicals; epidemiology--genomics--liver cancer--Native American--risk factors; Dewey: 616.362
  • Rights: legaldeposit
  • Publication Details: John Wiley & Sons Ltd
  • Abstract: Abstract: Background & Aims:

    Most regions of the world have ≤3 co‐circulating hepatitis B virus (HBV) genotypes, which limits direct comparisons of hepatocellular carcinoma (HCC) risk among HBV‐infected persons by genotype. We evaluated HCC incidence by HBV genotype in a cohort of Alaska Native (AN) persons where five HBV genotypes (A, B, C, D, F) have been identified.

    Methods:

    Our cohort comprised AN persons with chronic HBV infection identified during 1983–2012 who consented to participate in this study. Cohort persons were offered annual hepatitis B e antigen (HBeAg) testing and semi‐annual HCC screening. We developed a logistic regression model to compare HCC risk by genotype, adjusting for age, sex, region and HBeAg status.

    Results:

    Among the 1235 consenting study participants, 711 (57.6%) were male, 510 (41.3%) were HBeAg positive at cohort entry and 43 (3.5%) developed HCC. The HBV genotype was known for 1142 (92.5%) persons (13.5% A, 3.9% B, 6.7% C, 56.9% D, 19.0% F). The HCC incidence/1000 person‐years of follow‐up for genotypes A, B, C, D and F was 1.3, 0, 5.5, 0.4 and 4.2 respectively. Compared with persons with HBV genotype B/D infection, the HCC risk was higher for persons with genotypes A [adjusted odds ratio (aOR): 3.9, 95% confidence interval (CI): 1.14–13.74], C (aOR: 16.3, 95% CI: 5.20–51.11) and F (aOR: 13.9, 95% CI: 5.30–36.69).

    Conclusion:

    HBV genotype is independently associated with HCC risk. AN persons with genotypes A, C and F are at higher risk compared with genotypes B or D.


  • Identifier: System Number: LDEAvdc_100036612320.0x000001; Journal ISSN: 1478-3223; 10.1111/liv.13129
  • Publication Date: 2016
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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