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Folic Acid Intake and Neural Tube Defects

El-Shabrawi, Mortada H. et al.

Medicine. Volume 94:Issue 37 (2015, September 12th) -- Lippincott, Williams & Wilkins

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  • Title:
    Folic Acid Intake and Neural Tube Defects
  • Author: El-Shabrawi, Mortada H.;
    Kamal, Naglaa Mohamed;
    Elhusseini, Mona Abbas;
    Hussein, Laila;
    Abdallah, Enas Abdallah Ali;
    Ali, Yahia Zakaria Abdelalim;
    Azab, Ahmed Abelfattah;
    Salama, Mostafa Abdelazim;
    Kassab, Muna;
    Krawinkel, Michael;
    Zhu., Xiaolin
  • Found In: Medicine. Volume 94:Issue 37 (2015, September 12th)
  • Journal Title: Medicine
  • Subjects: Médecine--Périodiques; Periodicals; Medicine--Periodicals; Geneeskunde; Medicine; Dewey: 610.5
  • Rights: legaldeposit
  • Publication Details: Lippincott, Williams & Wilkins
  • Abstract: <x xml:space="preserve">Abstract</x> Abstract

    Neural tube defects (NTDs) are a group of congenital malformations with worldwide distribution and complex etiopathogenesis. Folic acid plays a pivotal role in their prevention. We aimed to identify the protective effect of folic acid intake against NTDs and its dependence on different socioeconomic and environmental factors in a cohort of mothers in Egypt.

    A cross-sectional study was carried over a period of 12 months on mothers who gave birth to babies with NTDs (group 1) and a control group with healthy offsprings (group 2). Both groups completed 2 questionnaires: food frequency questionnaire targeting the daily folate intake, and socioeconomic status and medical history questionnaire.

    Both groups of mothers received folate <800 μg/day, recommended for pregnant women. A strong association was detected between NTDs and urban residency with medium educated mothers, with negative consanguinity, who had folate intake < 400 μg daily, and who had their food long cooked. Each of these factors separately had a limited impact to cause NTDs, but when present together they did augment each other. Interestingly enough is the role of fava bean, cauliflower, spinach, and mango in predisposing of NTDs in the presence of the above-mentioned factors.

    The protective effect of folic acid intake against NTDs may depend on the synergism of different socioeconomic and environmental factors (which differ from country to another). In Egypt, females especially the medium-educated who live in urban areas should be well-informed with the value of folate intake in the periconceptional period.


  • Identifier: ETOClsidyv9a957d98; System Number: LDEAvdc_100026658285.0x000001; Journal ISSN: 0025-7974; 10.1097/MD.0000000000001395
  • Publication Date: 2015
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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