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Design and characterization of an economical 192Ir hemi-brain small animal irradiator

Grams, Michael P. et al.

International journal of radiation biology. Volume 90:Number 10 (2014, October); pp 936-942 -- Taylor & Francis

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  • Title:
    Design and characterization of an economical 192Ir hemi-brain small animal irradiator
  • Author: Grams, Michael P.;
    Wilson, Zachary C.;
    Sio, Terence T.;
    Beltran, Chris J.;
    Tryggestad, Erik J.;
    Gupta, Shiv K.;
    Blackwell, Charles R.;
    McCollough, Kevin P.;
    Sarkaria, Jann N.;
    Furutani, Keith M.
  • Found In: International journal of radiation biology. Volume 90:Number 10 (2014, October); pp 936-942
  • Journal Title: International journal of radiation biology
  • Subjects: Radiation--Physiological effect--Periodicals; Radiobiology--Periodicals; Dewey: 571.45
  • Rights: legaldeposit
  • Publication Details: Taylor & Francis
  • Abstract: Abstract

    Purpose: To describe the design and dosimetric characterization of a simple and economical small animal irradiator.

    Materials and methods: A high dose rate (HDR) 192Ir brachytherapy source from a commercially available afterloader was used with a 1.3 cm thick tungsten collimator to provide sharp beam penumbra suitable for hemi-brain irradiation of mice. The unit was equipped with continuous gas anesthesia to allow robust animal immobilization. Dosimetric characterization of the device was performed with Gafchromic film measurements.

    Results: The tungsten collimator provided a sharp penumbra suitable for hemi-brain irradiation, and dose rates on the order of 200 cGy/minute were achieved. The sharpness of the penumbra attainable with this device compares favorably to those measured experimentally for 6 MV photons, and 6 and 20 MeV electron beams from a linear accelerator, and was comparable to those measured for a 300 kVp orthovoltage beam and a Monte Carlo simulated 90 MeV proton beam.

    Conclusions: Due to its simplicity and low cost, the apparatus described is an attractive alternative for small animal irradiation experiments requiring steep dose gradients.


  • Identifier: ETOClsidyv8d32c305; System Number: LDEAvdc_100024950488.0x000001; Journal ISSN: 0955-3002; 10.3109/09553002.2014.922719
  • Publication Date: 2014
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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