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Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy

Yang, Xian‐Zhu et al.

Advanced materials. Volume 26:Number 6 (2014, January 9th); pp 931-936 -- Wiley-VCH

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  • Title:
    Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy
  • Author: Yang, Xian‐Zhu;
    Du, Xiao‐Jiao;
    Liu, Yang;
    Zhu, Yan‐Hua;
    Liu, Yang‐Zhong;
    Li, Ya‐Ping;
    Wang, Jun
  • Found In: Advanced materials. Volume 26:Number 6 (2014, January 9th); pp 931-936
  • Journal Title: Advanced materials
  • Subjects: Chemical vapor deposition--Periodicals; Materials--Periodicals; Dewey: 620.11
  • Rights: legaldeposit
  • Publication Details: Wiley-VCH
  • Abstract: <x xml:space="preserve">Abstract</x>

    Rationally designed PIC nanoparticles as next‐generation delivery system: we have developed a core–shell–corona PIC nanoparticle NP/Pt@PPC‐DA as a next‐generation delivery system. NP/Pt@PPC‐DA exhibits prolonged circulation and enhanced drug accumulation in tumors. Subsequently, tumor pH leads to the release of NP/Pt, which facilitates cellular uptake followed by rapid intracellular cisplatin release. Using this delivery strategy cisplatin‐resistant tumor growth in a murine xenograft model has been successfully suppressed.


  • Identifier: ETOClsidyv876ebde4; System Number: LDEAvdc_100024779648.0x000001; Journal ISSN: 0935-9648; 10.1002/adma.201303360
  • Publication Date: 2014
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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