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Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants

Klein, Pontus et al.

The EMBO journal. Volume 33:Number 4 (2014); pp 341-355 -- WILEY-VCH Verlag GmbH & Co. KGaA

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  • Title:
    Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants
  • Author: Klein, Pontus;
    Müller‐Rischart, Anne Kathrin;
    Motori, Elisa;
    Schönbauer, Cornelia;
    Schnorrer, Frank;
    Winklhofer, Konstanze F;
    Klein, Rüdiger
  • Found In: The EMBO journal. Volume 33:Number 4 (2014); pp 341-355
  • Journal Title: The EMBO journal
  • Subjects: Molecular biology--Periodicals; Dewey: 572.805
  • Rights: legaldeposit
  • Publication Details: WILEY-VCH Verlag GmbH & Co. KGaA
  • Abstract: Synopsis

    Glial cell line derived neurotrophic factor (GDNF) improves survival in toxin‐models of Parkinson's disease and is currently undergoing clinical development, however the protective mechanism is elusive. This study provides evidence that the GDNF receptor Ret rescues defects of a genetic Parkinson model and proposes a new mechanism‐of‐action.

    Active Ret overexpression rescues muscle degeneration and mitochondrial morphology in muscles and dopamine neurons in Pink1 mutant Drosophila.

    In human neuroblastoma cells, GDNF treatment rescues mitochondrial fragmentation caused by Pink1 knockdown.

    Ret signaling improves mitochondrial respiration and activity of complex I, providing a potential novel mechanism for the protective effect of GDNF/Ret.


  • Identifier: ETOClsidyv874d5bf2; System Number: LDEAvdc_100024766189.0x000001; Journal ISSN: 0261-4189; 10.1002/embj.201284290
  • Publication Date: 2014
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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