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Green Synthesis and Biological Evaluation of New Di‐α‐aminophosphonate Derivatives as Cytotoxic Agents

Uma Maheswara Rao, Kunda et al.

Archiv der Pharmazie. Volume 346:Issue 12 (2013, December); pp 851-859 -- Wiley-VCH Verlag & Co. KGaA

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  • Title:
    Green Synthesis and Biological Evaluation of New Di‐α‐aminophosphonate Derivatives as Cytotoxic Agents
  • Author: Uma Maheswara Rao, Kunda;
    Namkoong, Sim;
    Yu, Hwan‐Chul;
    Park, Junsoo;
    Chung, Chan‐Moon;
    Oh, Se Young
  • Found In: Archiv der Pharmazie. Volume 346:Issue 12 (2013, December); pp 851-859
  • Journal Title: Archiv der Pharmazie
  • Subjects: Pharmaceutical chemistry--Periodicals; Pharmacology--Periodicals; Dewey: 615.19
  • Rights: legaldeposit
  • Publication Details: Wiley-VCH Verlag & Co. KGaA
  • Abstract: Abstract

    A series of novel di‐α‐aminophosphonate derivatives were synthesized by a one‐pot method in the presence of PEG–H2O under ultrasonic irradiation and were characterized by IR, 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were evaluated for their cytotoxic activities against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7 in vitro by the MTT method. All compounds showed moderate cytotoxic activity on both cell lines, and compounds 4b and 4c showed marked activity.


  • Identifier: ETOClsidyv872f9c01; System Number: LDEAvdc_100024688187.0x000001; Journal ISSN: 0365-6233; 10.1002/ardp.201300249
  • Publication Date: 2013
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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