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Clinical outcome after resection of early-stage hilar cholangiocarcinoma

Stremitzer, Stefan

European journal of surgical oncology. Volume 45:Number 2 (2019, February); pp 213-217 -- Elsevier Ltd

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  • Title:
    Clinical outcome after resection of early-stage hilar cholangiocarcinoma
  • Author: Stremitzer, Stefan;
    Jones, Robert P.;
    Quinn, Leonard M.;
    Fenwick, Stephen W.;
    Diaz-Nieto, Rafael;
    Poston, Graeme J.;
    Malik, Hassan Z.
  • Found In: European journal of surgical oncology. Volume 45:Number 2 (2019, February); pp 213-217
  • Journal Title: European journal of surgical oncology
  • Subjects: Cancer--Chirurgie--Périodiques; Cancérologie--Périodiques; Medical Oncology--Periodicals; Neoplasms--surgery--Periodicals; Electronic journals--Medicine; Electronic journals--Sciences; Cancer--Surgery--Periodicals; Electronic journals; Oncology--Periodicals; Chirurgie (geneeskunde); Oncologie; Hilar cholangiocarcinoma--Early-stage tumour--Liver resection--Clinical outcome; Dewey: 616.994059005
  • Rights: Licensed
  • Publication Details: Elsevier Ltd
  • Abstract: Abstract Background Liver transplantation in patients with unresectable early-stage (<3 cm, node negative) hilar cholangiocarcinoma has been recently reported to be associated with longer survival compared to liver resection and therefore suggested as potential treatment option also in resectable disease. Here, we investigated the outcome of resection in early-stage tumours as the standard of care in an experienced European centre. Methods Patients with de novo resectable hilar cholangiocarcinomas who underwent liver resection between mid-2009 and December 2017 were classified as early-stage (<3 cm and node negative) or later-stage tumours (≥3 cm and/or node positive), and were investigated with respect to clinical outcome. Results Fifty-six patients were analyzed of whom 17 had early-stage tumours and 39 had later-stage tumours. The sex ratio (m:f) was 30:26. The median age was 65 years (range 33–80). The median follow-up was 17.0 months (range 0.7–92.4). 5-year overall survival (OS) rates were 82% in patients with early-stage tumours and 23% in patients with later-stage tumours, respectively. Median OS was 89.9 months and 27.6 months, respectively (HR 0.25 (95% CI 0.08–0.84), P  = 0.024). Conclusions In an experienced European centre, 5-year survival rates after liver resection for early-stage hilar cholangiocarcinoma are comparable with reported outcomes after transplantation. The results of this study question the value of liver transplantation in this setting, especially with respect to the shortage of transplantable organs worldwide.
  • Identifier: System Number: ETOCvdc_100093901912.0x000001; Journal ISSN: 0748-7983; 10.1016/j.ejso.2018.09.008
  • Publication Date: 2019
  • Physical Description: Electronic
  • Shelfmark(s): 3829.745500
  • UIN: ETOCvdc_100093901912.0x000001

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