skip to main content
Show Results with:

Measuring the Impact of Delayed Cerebral Ischemia on Neuropsychological Outcome After Aneurysmal Subarachnoid Hemorrhage—Protocol of a Swiss Nationwide Observational Study (MoCA–DCI Study)

Stienen, Martin N et al.

Neurosurgery. Volume 84:Issue 5 (2019); pp 1124-1132 -- Oxford University Press

Online access

  • Title:
    Measuring the Impact of Delayed Cerebral Ischemia on Neuropsychological Outcome After Aneurysmal Subarachnoid Hemorrhage—Protocol of a Swiss Nationwide Observational Study (MoCA–DCI Study)
  • Author: Stienen, Martin N;
    Fung, Christian;
    Bijlenga, Philippe;
    Zumofen, Daniel W;
    Maduri, Rodolfo;
    Robert, Thomas;
    Seule, Martin A;
    Marbacher, Serge;
    Geisseler, Olivia;
    Brugger, Peter;
    Gutbrod, Klemens;
    Chicherio, Christian;
    Monsch, Andreas U;
    Beaud, Valérie;
    Rossi, Stefania;
    Früh, Severin;
    Schmid, Nicole;
    Smoll, Nicolas R;
    Keller, Emanuela;
    Regli, Luca
  • Found In: Neurosurgery. Volume 84:Issue 5 (2019); pp 1124-1132
  • Journal Title: Neurosurgery
  • Subjects: Nervous system--Surgery--Periodicals; Delayed cerebral ischemia--Cognitive disorders--Montreal Cognitive Assessment--Outcome--Reliability--Stroke--Subarachnoid hemorrhage; Dewey: 617.48005
  • Rights: Licensed
  • Publication Details: Oxford University Press
  • Abstract: Abstract: BACKGROUND:

    The exact relationship between delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) and neuropsychological impairment remains unknown, as previous studies lacked a baseline examination after aneurysm occlusion but before the DCI-period. Neuropsychological evaluation of acutely ill patients is often applied in a busy intensive care unit (ICU), where distraction represents a bias to the obtained results.

    OBJECTIVE:

    To evaluate the relationship between DCI and neuropsychological outcome after aSAH by comparing the Montreal Cognitive Assessment (MoCA) results in aSAH patients with and without DCI at 3 mo with a baseline examination before the DCI-period (part 1). To determine the reliability of the MoCA, when applied in an ICU setting (part 2).

    METHODS:

    Prospective, multicenter, and observational study performed at all Swiss neurovascular centers. For part 1, n = 240 consecutive aSAH patients and for part 2, n = 50 patients with acute brain injury are recruited.

    EXPECTED OUTCOMES:

    Part 1: Effect size of the relationship between DCI and neuropsychological outcome (MoCA). Part 2: Reliability measures for the MoCA.

    DISCUSSION:

    The institutional review boards approved this study on July 4, 2017 under case number BASEC 2017-00103. After completion, the results will be offered to an international scientific journal for peer-reviewed publication. This study determines the exact impact of DCI on the neuropsychological outcome after aSAH, unbiased by confounding factors such as early brain injury or patient-specific characteristics. The study provides unique insights in the neuropsychological state of patients in the early period after aSAH.


  • Identifier: System Number: ETOCvdc_100087531271.0x000001; Journal ISSN: 0148-396X; 10.1093/neuros/nyy155
  • Publication Date: 2019
  • Physical Description: Electronic
  • Shelfmark(s): 6081.582000
  • UIN: ETOCvdc_100087531271.0x000001

Searching Remote Databases, Please Wait