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SUVmax and Tumour Location in PET-CT Predict Oncogene Status in Lung Cancer

Putora, Paul M. et al.

Oncology research and treatment. Volume 39:Issue 11 (2016); pp 681-686 -- S. Karger AG

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  • Title:
    SUVmax and Tumour Location in PET-CT Predict Oncogene Status in Lung Cancer
  • Author: Putora, Paul M.;
    Szentesi, Kinga;
    Glatzer, Markus;
    Rodriguez, Regulo;
    Müller, Joachim;
    Baty, Florent;
    Früh, Martin
  • Found In: Oncology research and treatment. Volume 39:Issue 11 (2016); pp 681-686
  • Journal Title: Oncology research and treatment
  • Subjects: Anaplastic lymphoma kinase--EGFR--Positron emission tomography--Lung neoplasms; Dewey: 616.994005
  • Rights: Licensed
  • Publication Details: S. Karger AG
  • Abstract:

    Background: In non-small cell lung cancer, anaplastic lymphoma kinase gene rearrangement ( ALK +) and epidermal growth factor receptor mutations ( EGFR +) are targetable with tyrosine kinase inhibitors. Patients and Methods: 27 patients with ALK + tumours, who underwent positron emission tomography-computed tomography (PET-CT) prior to any treatment, were identified. 2 equally sized control groups based on consecutive patients with EGFR + and EGFR / ALK wild-type (wt) were identified. The maximum standardized uptake value (SUVmax), tumour location (central vs. peripheral), as well as patient- and disease-specific characteristics were collected. Results: Mutation status was significantly associated with SUVmax(p < 0.008). The median SUVmaxof the primary tumour in the lung for ALK + patients (SUVmax13) was significantly higher compared to that of the EGFR + (SUVmax9.8, p = 0.010) and the EGFR / ALK wtgroup (SUVmax9.6, p = 0.022). No difference was observed between the EGFR + and the EGFR / ALK wtgroup (p = 0.961). Mutation status was also associated with primary tumour location (p = 0.001). There was a significantly lower rate of central tumours in the EGFR + group when compared to ALK + tumours (15%, p = 0.002). Among EGFR / ALK wttumours, 41% were central compared to 63% of ALK + tumours (p = 0.235). Conclusion: On initial PET-CT, ALK + primary lung tumours showed a higher SUVmaxand were more frequently centrally located while peripheral tumours were more likely to be EGFR +.


  • Identifier: System Number: ETOCvdc_100084882714.0x000001; Journal ISSN: 2296-5270; 10.1159/000450622
  • Publication Date: 2016
  • Physical Description: Electronic
  • Shelfmark(s): 6256.983450
  • UIN: ETOCvdc_100084882714.0x000001

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