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Inhibition of bleomycin-induced pulmonary fibrosis in mice by the novel peptide EZY-1 purified from Eucheuma

YuThese authors contributed equally to this work., Huajun et al.

Food & function. Volume 10:Issue 6 (2019); pp 3198-3208 -- Royal Society of Chemistry

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  • Title:
    Inhibition of bleomycin-induced pulmonary fibrosis in mice by the novel peptide EZY-1 purified from Eucheuma
  • Author: YuThese authors contributed equally to this work., Huajun;
    Zhang, Zhao;
    Huang, Hui;
    Wang, Yajun;
    Lin, Biyun;
    Wu, Shang;
    Ma, Jingyao;
    Chen, Baoan;
    He, Zhan;
    Wu, Jun;
    Zhao, Zuguo;
    Zhang, Haitao
  • Found In: Food & function. Volume 10:Issue 6 (2019); pp 3198-3208
  • Journal Title: Food & function
  • Subjects: Food--Analysis--Periodicals; Food--Composition--Periodicals; Nutrition--Periodicals; Dewey: 664.07
  • Rights: Licensed
  • Publication Details: Royal Society of Chemistry
  • Abstract:

    For the first time, a new 16-amino-acid peptide was isolated fromEucheuma, an edible seaweed, and named EZY-1. EZY-1 was used to interfere with bleomycin-induced mice pulmonary fibrosis. The target proteins of EZY-1 were screened by anin vitropull-down method combined with LC-MS/MS. The results showed that EZY-1 can inhibit the idiopathic pulmonary fibrosis (IPF) induced by bleomycin. The potency and safety of EZY-1 are superior to those of the drug used for clinical treatment, pirfenidone. The results showed that EZY-1 suppresses the TGF-β/Smad, PI3K-Akt-mTOR, Rac1-PAK2-cAb1 and MAPK signal transduction pathways. Proteins such as ERK, Akt, PDGF receptor β, vitronectin, raptor and SHP2 exhibited binding to EZY-1 in anin vitropull-down assay combined with LC-MS/MS analysis. EZY-1 was confirmed to be an effective component ofEucheumain the inhibition of IPF. The signalling pathways and target proteins of EZY-1 were preliminarily predicted. This study lays the foundation for the development of new drugs fromEucheumafor the treatment of IPF.


  • Identifier: System Number: ETOCvdc_100083192306.0x000001; Journal ISSN: 2042-6496; 10.1039/c9fo00308h
  • Publication Date: 2019
  • Physical Description: Electronic
  • Shelfmark(s): 3977.038457
  • UIN: ETOCvdc_100083192306.0x000001

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