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Screening for familial hypercholesterolaemia in primary care: Time for general practice to play its part

Brett, Tom et al.

Atherosclerosis. Volume 277: (2018, October); pp 399-406 -- Elsevier Ireland Ltd

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  • Title:
    Screening for familial hypercholesterolaemia in primary care: Time for general practice to play its part
  • Author: Brett, Tom;
    Qureshi, Nadeem;
    Gidding, Samuel;
    Watts, Gerald F.
  • Found In: Atherosclerosis. Volume 277: (2018, October); pp 399-406
  • Journal Title: Atherosclerosis
  • Subjects: Arteriosclerosis--Periodicals; Familial hypercholesterolaemia--Primary care--Screening; Electronic journals; Dewey: 616.136
  • Rights: Licensed
  • Publication Details: Elsevier Ireland Ltd
  • Abstract: Abstract Fifty per cent of first-degree relatives of index cases with familial hypercholesterolemia (FH) inherit the disorder. Despite cascade screening being the most cost-effective method for detecting new cases, only a minority of individuals with FH are currently identified. Primary care is a key target area to increase identification of new index cases and initiate cascade screening, thereby finding close relatives of all probands. Increasing public and health professional awareness about FH is essential. In the United Kingdom and in Australia, most of the population are reviewed by a General Practitioner (GP) at least once over a three-year period, offering opportunities to check for FH as part of routine clinical consultations. Such opportunistic approaches can be supplemented by systematically searching electronic health records with information technology tools that identify high risk patients. GPs can help investigate and implement results of this data retrieval. Current evidence suggests that early detection of FH and cascade testing meet most of the criteria for a worthwhile screening program. Among heterozygous patients the long latent period before the expected onset of coronary artery disease provides an opportunity for initiating effective drug and lifestyle changes. The greatest challenge for primary care is to implement an efficacious model of care that incorporates sustainable identification and management pathways. Highlights A minority of familial hypercholesteroleamia (FH) cases are currently identified. FH meets World Health Organisation (WHO) criteria for screening but new models of detection are required. Primary care practice is a useful site for FH detection. Early recognition of FH provides an excellent opportunity for preventing coronary artery disease (CAD). Increasing public and health professional awareness is essential for screening success.
  • Identifier: System Number: ETOCvdc_100081970979.0x000001; Journal ISSN: 0021-9150; 10.1016/j.atherosclerosis.2018.08.019
  • Publication Date: 2018
  • Physical Description: Electronic
  • Shelfmark(s): 1765.874000
  • UIN: ETOCvdc_100081970979.0x000001

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