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Comparative aspects of the care of familial hypercholesterolemia in the "Ten Countries Study"

Pang, Jing et al.

Journal of clinical lipidology. Volume 13:Number 2 (2019, March 20th); pp 287-300 -- Elsevier

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  • Title:
    Comparative aspects of the care of familial hypercholesterolemia in the "Ten Countries Study"
  • Author: Pang, Jing;
    Chan, Dick C.;
    Hu, Miao;
    Muir, Lauretta A.;
    Kwok, See;
    Charng, Min-Ji;
    Florkowski, Christopher M.;
    George, Peter M.;
    Lin, Jie;
    Loi, Do Doan;
    Marais, A. David;
    Nawawi, Hapizah M.;
    Gonzalez-Santos, Lourdes E.;
    Su, Ta-Chen;
    Truong, Thanh Huong;
    Santos, Raul D.;
    Soran, Handrean;
    Tomlinson, Brian;
    Yamashita, Shizuya;
    Ademi, Zanfina;
    Watts, Gerald F.
  • Found In: Journal of clinical lipidology. Volume 13:Number 2 (2019, March 20th); pp 287-300
  • Journal Title: Journal of clinical lipidology
  • Subjects: Diabète--Périodiques; Hypertension artérielle--Périodiques; Lipides--Métabolisme, Troubles du--Périodiques; Obésité--Périodiques; Lipoproteins--drug effects--Periodicals; Lipids--Metabolism--Disorders--Periodicals; Lipids--Periodicals; Lipids; Lipids--Metabolism--Disorders; Periodicals; Familial hypercholesterolemia--Health care--Services--Facilities--Asia-pacific region--Southern hemisphere; Electronic journals; Dewey: 616.3997005
  • Rights: Licensed
  • Publication Details: Elsevier
  • Abstract: Background There is a lack of information on the health care of familial hypercholesterolemia (FH). Objective The objective of this study was to compare the health care of FH in countries of the Asia-Pacific region and Southern Hemisphere. Methods A series of questionnaires were completed by key opinion leaders from selected specialist centers in 12 countries concerning aspects of the care of FH, including screening, diagnosis, risk assessment, treatment, teaching/training, and research; the United Kingdom (UK) was used as the international benchmark. Results The estimated percentage of patients diagnosed with the condition was low (overall <3%) in all countries, compared with ∼15% in the UK. Underdetection of FH was associated with government expenditure on health care (ϰ = 0.667, P  < .05). Opportunistic and systematic screening methods, and the Dutch Lipid Clinic Network criteria were most commonly used to detect FH; genetic testing was infrequently used. Noninvasive imaging of coronary calcium and/or carotid plaques was underutilized in risk assessment. Patients with FH were generally not adequately treated, with <30% of patients achieving guideline recommended low-density lipoprotein cholesterol targets on conventional therapies. Treatment gaps included suboptimal availability and use of lipoprotein apheresis and proprotein convertase subtilsin-kexin type 9 inhibitors. A deficit of FH registries, training programs, and publications were identified in less economically developed countries. The demonstration of cost-effectiveness for cascade screening, genetic testing, and specialized treatments were significantly associated with the availability of subsidies from the health care system (ϰ = 0.571–0.800, P  < .05). Conclusion We identified important gaps across the continuum of care for FH, particularly in less economically developed countries. Wider implementation of primary and pediatric care, telehealth services, patient support groups, education/training programs, research activities, and health technology assessments are needed to improve the care of patients with FH in these countries. Highlights We identified important gaps across the continuum of care for familial hypercholesterolemia (FH) in 12 countries. Estimated percentage of patients diagnosed with FH was low (overall <3%). Diagnosis of FH was associated with government expenditure on health care. Use of lipoprotein apheresis and PCSK9 inhibitors were limited in most countries. Availability of subsidy from the health care system is important for the care of FH.
  • Identifier: System Number: ETOCvdc_100081940999.0x000001; Journal ISSN: 1933-2874; 10.1016/j.jacl.2019.01.009
  • Publication Date: 2019
  • Physical Description: Electronic
  • Shelfmark(s): 4958.545500
  • UIN: ETOCvdc_100081940999.0x000001

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