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Over-expression of CD8+ T-cell activation is associated with decreased CD4+ cells in patients seeking treatment of Alcohol Use Disorder

Zuluaga, Paola et al.

Drug and alcohol dependence. Volume 180: (2017, November 1st); pp 7-13 -- Elsevier

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  • Title:
    Over-expression of CD8+ T-cell activation is associated with decreased CD4+ cells in patients seeking treatment of Alcohol Use Disorder
  • Author: Zuluaga, Paola;
    Sanvisens, Arantza;
    Martínez-Cáceres, Eva;
    Teniente, Aina;
    Tor, Jordi;
    Muga, Robert
  • Found In: Drug and alcohol dependence. Volume 180: (2017, November 1st); pp 7-13
  • Journal Title: Drug and alcohol dependence
  • Subjects: Alcoholism--Periodicals; Drug abuse--Periodicals; Alcohol use disorder--T cell activation--Immunophenotyping--CD4+ T cell--CD8+ T cell; Dewey: 616.86
  • Rights: Licensed
  • Publication Details: Elsevier
  • Abstract: Highlights Patients with alcohol use disorder (AUD) have more CD8 + immune activation than healthy individuals. The excess of activated CD8 + T cells correlates inversely with the CD4 + T cells. An activation indicator would be useful in clinical practice to identify risk of immunosuppression. Abstract Introduction Harmful alcohol consumption may have an impact on the adaptive immune system through an imbalance in T cell subpopulations and changes in cell activation. We aimed to analyze profiles of CD4 and CD8 T cell activation in patients with alcohol use disorder (AUD). Methods We used a cross-sectional study with patients seeking treatment of the disorder. Blood samples for immunophenotyping were obtained at admission. Profiles of T cell activation were defined: (I) CD38 + /HLA-DR +, (II) CD38 + /HLA-DR −, (III) CD38 − /HLA-DR +, (IV) CD38 − /HLA-DR − and compared with healthy controls. We calculated a CD8 + T cell activation indicator (AI) that was defined as the quotient of non-activated cells (CD38 − /HLA-DR − ) and activated cells (CD38 + /HLA-DR + ). Results 60 patients were eligible (83% M); median age was 49 years [IQR: 44–54] and alcohol consumption was 145 g/day [IQR: 90–205]. Mean ± SD of CD38 + /HLA-DR − was 50.3 ± 50.6 cells/μL in patients and 33.5 ± 24.5 cells/μL in controls (p = 0.03), for the CD38 − /HLA-DR + it was 61 ± 62.2 cells/μL in patients and 21.2 ± 17.3 cells/μL in controls (p < 0.001) and for the CD38 + /HLA-DR + it was 20.2 ± 15.6 cells/μL in patients and 10.8 ± 10.3 cells/μL in controls (p < 0.001). In patients, an inverse correlation was observed between absolute number and percentage of CD4 + T cells, and the percentage of CD38 + /HLA-DR + CD8 + T cells (r = 0.37, p = 0.003; r = 0.2, p = 0.086, respectively). Conclusions Patients with AUD have an increased expression of immune activation with respect to healthy individuals. This excess of activated CD8 + T cells correlates with the absolute CD4 + T cells.
  • Identifier: System Number: ETOCvdc_100078377588.0x000001; Journal ISSN: 0376-8716; 10.1016/j.drugalcdep.2017.07.023
  • Publication Date: 2017
  • Physical Description: Electronic
  • Shelfmark(s): 3627.890000
  • UIN: ETOCvdc_100078377588.0x000001

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