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Regulation of Salmonella-host cell interactions via the ubiquitin system

Herhaus, Lina; Dikic, Ivan

International journal of medical microbiology: IJMM. Volume 308:Number 1 (2018, January); pp 176-184 -- Elsevier Science

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  • Title:
    Regulation of Salmonella-host cell interactions via the ubiquitin system
  • Author: Herhaus, Lina;
    Dikic, Ivan
  • Found In: International journal of medical microbiology: IJMM. Volume 308:Number 1 (2018, January); pp 176-184
  • Journal Title: International journal of medical microbiology: IJMM
  • Subjects: Communicable diseases--Periodicals; Microbiology--Periodicals; Parasitology--Periodicals; Virology--Periodicals; Salmonella--Ubiquitin--Innate immunity--Effector proteins--E3 ligases--Intracellular pathogens; Dewey: 616.9201
  • Rights: Licensed
  • Publication Details: Elsevier Science
  • Abstract: Graphical abstract Abstract Salmonella infections cause acute intestinal inflammatory responses through the action of bacterial effector proteins secreted into the host cytosol. These proteins promote Salmonella survival, amongst others, by deregulating the host innate immune system and interfering with host cell ubiquitylation signaling. This review describes the recent findings of dynamic changes of the host ubiquitinome during pathogen infection, how bacterial effector proteins modulate the host ubiquitin system and how the host innate immune system counteracts Salmonella invasion by using these pathogens as signaling platforms to initiate immune responses.
  • Identifier: System Number: ETOCvdc_100078061493.0x000001; Journal ISSN: 1438-4221; 10.1016/j.ijmm.2017.11.003
  • Publication Date: 2018
  • Physical Description: Electronic
  • Shelfmark(s): 4542.346000
  • UIN: ETOCvdc_100078061493.0x000001

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