skip to main content
Show Results with: Show Results with:

Associations of oxytocin and vasopressin plasma levels with neurocognitive, social cognitive and meta cognitive function in schizophrenia

Aydın, Orkun et al.

Psychiatry research. Volume 270: (2018, December); pp 1010-1016 -- Elsevier

Online access

  • Title:
    Associations of oxytocin and vasopressin plasma levels with neurocognitive, social cognitive and meta cognitive function in schizophrenia
  • Author: Aydın, Orkun;
    Lysaker, Paul H.;
    Balıkçı, Kuzeymen;
    Ünal-Aydın, Pınar;
    Esen-Danacı, Ayşen
  • Found In: Psychiatry research. Volume 270: (2018, December); pp 1010-1016
  • Journal Title: Psychiatry research
  • Subjects: Psychiatrie--Périodiques; Psychiatry--periodicals; Psychiatry--Periodicals; Metacognition--Oxytocin--Vasopressin--Social cognition--Neurocognition; WCST--RMET--MAS-A--IPII--OT--VP--ToM; Dewey: 616.89
  • Rights: Licensed
  • Publication Details: Elsevier
  • Abstract: Highlights We assessed plasma OT and VP in 34 schizophrenia patients and 31 healthy controls. Group comparisons revealed lower plasma OT levels in the schizophrenia group. Plasma VP levels did not differ between groups. Lower levels of OT was associated with poorer metacognition in schizophrenia. OT, neurocognition and social cognition contributed uniquely to the prediction of metacognition Abstract Many with schizophrenia experiences deficits in social cognition, neurocognition and metacognition. Yet the biological mechanisms which may underpin these cognitive deficits are poorly understood. Two candidate causes of these deficits are disturbances in oxytocin (OT) and vasopressin (VP). To explore this we assessed plasma OT and VP in 34 schizophrenia patients and 31 healthy controls. We also concurrently assessed social cognition using the Reading the Mind from the Eyes test, neurocognition using the Wisconsin Card Sorting Test and metacognition using the Metacognitive Assessment Scale-Abbreviated. Group comparisons revealed lower plasma OT levels in the schizophrenia group. Plasma VP levels did not differ between groups. Correlations revealed that lower levels of OT were associated with poorer levels of metacognitive functioning in the schizophrenia group but not poorer social cognition or neurocognition. In a stepwise multiple regression, plasma OT level, neurocognition and social cognition contributed uniquely to the prediction of metacognition in the schizophrenia group. Results may suggest that disturbance in OT is linked with deficits in metacognition and may interact with other forms of cognitive deficits, interfering with the person's abilities to form a complex and integrated sense of self and others.
  • Identifier: System Number: ETOCvdc_100073265704.0x000001; Journal ISSN: 0165-1781; 10.1016/j.psychres.2018.03.048
  • Publication Date: 2018
  • Physical Description: Electronic
  • Shelfmark(s): 6946.263700
  • UIN: ETOCvdc_100073265704.0x000001

Searching Remote Databases, Please Wait