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TRNA fragmentation and protein translation dynamics in the course of kidney injury

Mami, Iadh; Pallet, Nicolas

RNA biology. Volume 15:Number 9 (2018, September 2nd); pp 1147-1156 -- Taylor & Francis

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  • Title:
    TRNA fragmentation and protein translation dynamics in the course of kidney injury
  • Author: Mami, Iadh;
    Pallet, Nicolas
  • Found In: RNA biology. Volume 15:Number 9 (2018, September 2nd); pp 1147-1156
  • Journal Title: RNA biology
  • Subjects: Molecular biology--Periodicals; RNA--Periodicals; Molecular biology; Periodicals; RNA; Acute kidney injury--endoplasmic reticulum stress--tiRNA--transfer RNA--unfolded protein response; Dewey: 572.8805
  • Rights: Licensed
  • Publication Details: Taylor & Francis
  • Abstract: ABSTRACT:

    Cells under stressful microenvironmental conditions initiate integrated molecular circuitries that aim at reducing general protein translation rates while redirecting protein synthesis toward a selective set of stress-response proteins. The consequence of the activation of this dynamic system is a reduction of the energy expenditure of the cell, and a metabolic rewiring that shapes adaptation under stress, which will, in fine, promote cell survival. In general, the translation initiation step is the prime target of translation reduction, with 2 molcular modules inhibiting translation initiation: the mechanistic target of Rapamycin complex 1, and the stress related kinases eIF2 kinases, which are all involved in the cellular responses to kidney injuries. tRNA (tRNA) dynamics and fragmentation have recently gained a considerable weight in the field of the non-coding RNA biology, and emerge as an important system for protein translation modulation under cellular stress. More precisely, stress-induced tRNA (tiRNA), the cleavage products of the ribonuclease angiogenin, are generated under various stress conditions, including oxidative stress and endoplasmic reticulum stress, and contribute to protein translation reprogramming in mammal cells. Current clinical and experimental evidence indicates that the angiogenin-tRNA fragmentation system is initiated under renal insults, and is involved in the tissue adaptation upon kidney injury. In addition, this system represents a potential source for minimally-invasive or non invasive biomarkers of early kidney injury. Besides RNA interference, tRNA fragments are likely involved in other fundamental cellular functions, including inflammation, and a better understanding of the molecular basis of tRNA functions will drive discoveries on the fundamental role of non coding RNA biology, as exemplified by microRNA, in the regulation of kidney homeostasis.

  • Identifier: System Number: ETOCvdc_100068612431.0x000001; Journal ISSN: 1547-6286; 10.1080/15476286.2015.1107704
  • Publication Date: 2018
  • Physical Description: Electronic
  • Shelfmark(s): 7993.991300
  • UIN: ETOCvdc_100068612431.0x000001

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