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The optimal time of day for statin administration: a review of current evidence

Awad, Kamal; Banach, Maciej

Current opinion in lipidology. Volume 29:Number 4 (2018, August); pp 340-345 -- Wolters Kluwer Health, Inc

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  • Title:
    The optimal time of day for statin administration: a review of current evidence
  • Author: Awad, Kamal;
    Banach, Maciej
  • Found In: Current opinion in lipidology. Volume 29:Number 4 (2018, August); pp 340-345
  • Journal Title: Current opinion in lipidology
  • Subjects: Lipids--Periodicals; evening--half-life--hydroxymethylglutarylCoA reductase inhibitors--morning--statins; Dewey: 572.574
  • Rights: Licensed
  • Publication Details: Wolters Kluwer Health, Inc
  • Abstract: Purpose of review:

    In humans, cholesterol biosynthesis varies diurnally, reaching its peak at night. Therefore, choosing the time of statin administration is critical because of their different half-lives. Dose timing becomes more important in patients with polypharmacy because it might affect their adherence to the statin therapy.

    Recent findings:

    Herein, we narratively summarized the available clinical studies ( n  = 17) and meta-analyses ( n  = 2) that compared the morning with the evening dose of statins in terms of safety and efficacy, with special focus on their low-density lipoprotein-lowering effects. We also explained the difference in efficacy results in case of short-acting compared with the long-acting statins and highlighted how flexibility in choosing the time of statin administration is important for better adherence.

    Summary:

    The current limited evidence suggests that short-acting statins should be given in the evening whereas long-acting statins could be given at any time of the day with allowing more patient-based choice (of timing) for better adherence. Lager RCTs with longer durations are recommended to extend and confirm the current evidence.


  • Identifier: System Number: ETOCvdc_100065943029.0x000001; Journal ISSN: 1473-6535; 10.1097/MOL.0000000000000524
  • Publication Date: 2018
  • Physical Description: Electronic
  • UIN: ETOCvdc_100065943029.0x000001

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