skip to main content
Show Results with:

"Auto-anti-IgE": Naturally occurring IgG anti-IgE antibodies may inhibit allergen-induced basophil activation

Chan, Yih-Chih et al.

The journal of allergy and clinical immunology. Volume 134:Issue 6 (2014); pp 1394-1401.e4 -- Elsevier

Online access

  • Title:
    "Auto-anti-IgE": Naturally occurring IgG anti-IgE antibodies may inhibit allergen-induced basophil activation
  • Author: Chan, Yih-Chih;
    Ramadani, Faruk;
    Santos, Alexandra F.;
    Pillai, Prathap;
    Ohm-Laursen, Line;
    Harper, Clare E.;
    Fang, Cailong;
    Dodev, Tihomir S.;
    Wu, Shih-Ying;
    Ying, Sun;
    Corrigan, Christopher J.;
    Gould, Hannah J.
  • Found In: The journal of allergy and clinical immunology. Volume 134:Issue 6 (2014); pp 1394-1401.e4
  • Journal Title: The journal of allergy and clinical immunology
  • Subjects: Allergy and Immunology; Hypersensitivity; Periodicals; Allergy--Periodicals; Electronic journals; Allergy; AA--ANA--APC--BAT--FACS--FITC--HDM--HRP--MFI--MP--NAA--NAC--PBS-T--PE--PEFR--RT--SPT; Asthma--autoantibodies--IgE--basophil activation--basophil inhibition; Dewey: 616.97
  • Rights: Licensed
  • Publication Details: Elsevier
  • Abstract: Background Naturally occurring IgE-specific IgG autoantibodies have been identified in patients with asthma and other diseases, but their spectrum of functions is poorly understood. Objective Address the hypothesis that: (i) IgG anti-IgE autoantibodies are detectable in the serum of all subjects but elevated in asthmatic patients regardless of atopic status as compared with controls; (ii) some activate IgE-sensitized basophils; and (iii) some inhibit allergen-induced basophil activation. Methods IgE-specific IgG autoantibodies were detected and quantified in sera using ELISA. Sera were examined for their ability to activate IgE-sensitized human blood basophils in the presence and absence of allergen using a basophil activation test, and to inhibit allergen binding to specific IgE on a rat basophilic cell line stably expressing human FcεRI. Results IgG autoantibodies binding to both free and FcεRI-bound IgE were detected in patients with atopic and non-atopic asthma, as well as controls. While some were able to activate IgE-sensitised basophils, others inhibited allergen-induced basophil activation, at least partly by inhibiting binding of IgE to specific allergen. Conclusion Naturally occurring IgG anti-IgE autoantibodies may inhibit, as well as induce, basophil activation. They act in a manner distinct from therapeutic IgG anti-IgE antibodies such as omalizumab. They may at least partly explain why atopic subjects who make allergen-specific IgE never develop clinical symptoms, and why omalizumab therapy is of variable clinical benefit in severe atopic asthma.
  • Identifier: System Number: ETOCvdc_100065722515.0x000001; Journal ISSN: 0091-6749; 10.1016/j.jaci.2014.06.029
  • Publication Date: 2014
  • Physical Description: Electronic
  • Shelfmark(s): 4927.100000
  • UIN: ETOCvdc_100065722515.0x000001

Searching Remote Databases, Please Wait